AB9913

Anti-TNRC6B Antibody

from rabbit, purified by affinity chromatography

• Sinônimo(s): Trinucleotide repeat-containing gene 6B protein
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• purificado por: affinity chromatography
• reatividade de espécies: human, ox
• reatividade da espécie (prevista por homologia): mouse (based on 100% sequence homology), rat (based on 100% sequence homology)
• técnica(s): immunocytochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• nº de adesão NCBI: NP_001155973
• nº de adesão UniProt: Q9UPQ9
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... TNRC6B(23112)

Descrição

Descrição geral

TNRC6B (trinucleotide repeat containing 6B) is a argonaute-associated protein that localizes to cytoplasmic P bodies and is essential for control of miRNA-guided mRNA cleavage. TNRC6B is one of the mammalian homologs of the metazoan GW182 and is required for well-organized miRNA repression. Studies suggest that TNRC6B-mediated miRNA silencing is promoted by the C-terminal silencing domain.

Especificidade

Antibody recognizes TNRC6B

Imunogênio

Epitope: N-terminan domain of TNRC6B

KLH-conjugated linear peptide corresponding to human TNRC6B.

Aplicação

Anti-TNRC6B Antibody is a Rabbit Polyclonal Antibody for detection of TNRC6B also known as Trinucleotide repeat-containing gene 6B protein & has been validated in WB, ICC & IP.

Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected TNRC6B in HeLa cells. (Zipprich, J., et al. (2009). RNA. 15:781–793.)

Research Category
Epigenetics & Nuclear Function

Research Sub Category
RNA Metabolism & Binding Proteins

Qualidade

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected TNRC6B on 10 µg of HeLa cell lysate.

Descrição-alvo

~150/190 kDa observed. (Meister, G., et al. (2005). Current Biology. 15:2149–2155). An uncharacterized band at ~39 kDa may be observed in some lysates.

forma física

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Nota de análise

Control
HeLa cell lysate

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable