8.52021

Fmoc-Val-OH

Novabiochem^®

• Sinônimo(s): Fmoc-Val-OH, N-α-Fmoc-L-valine
• Fórmula empírica (Notação de Hill): C₂₀H₂₁NO₄
• Número CAS: 68858-20-8
• Peso molecular: 339.39
• Número MDL: MFCD00037124
• Código UNSPSC: 12352209
• Número do índice EC: 272-515-0
• NACRES: NA.22

Propriedades

• Nível de qualidade: 400
• linha de produto: Novabiochem^®
• Ensaio: ≥98% (TLC); ≥98.0% (acidimetric); ≥99.0% (HPLC)
• Formulário: powder
• adequação da reação: reaction type: Fmoc solid-phase peptide synthesis
• fabricante/nome comercial: Novabiochem^®
• pf: 140-145 °C
• aplicação(ões): peptide synthesis
• grupo funcional: Fmoc
• temperatura de armazenamento: 2-30°C
• cadeia de caracteres SMILES: N(C(C(C)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI: 1S/C20H21NO4/c1-12(2)18(19(22)23)21-20(24)25-11-17-15-9-5-3-7-13(15)14-8-4-6-10-16(14)17/h3-10,12,17-18H,11H2,1-2H3,(H,21,24)(H,22,23)
• chave InChI: UGNIYGNGCNXHTR-UHFFFAOYSA-N

Descrição

Descrição geral

High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities.
Standard building block for introduction of valine amino-acid residues by Fmoc SPPS

Associated Protocols and Technical Articles
Fmoc-amino acids for Peptide Production
Cleavage and Deprotection Protocols for Fmoc SPPS

Aplicação

• Evaluation of Met-Val-Lys as a Renal Brush Border Enzyme-Cleavable Linker: This study explores using Fmoc-Val-OH in the development of renal-targeted drug delivery systems for enhanced therapeutic efficacy (Bendre et al., 2020).
• Enantioselective Ortho-CH Cross-Coupling of Diarylmethylamines with Organoborons: Reports the use of Fmoc-Val-OH in a new methodology for achieving high yields and enantioselectivity in cross-coupling reactions (Laforteza et al., 2015).
• AJIPHASE®: A Highly Efficient Synthetic Method for One-Pot Peptide Elongation: Demonstrates a novel approach using Fmoc-Val-OH for the scalable synthesis of peptides, showing significant improvements in efficiency and scalability (Takahashi et al., 2017).

Ligação

Replaces: 04-12-1039

Nota de análise

Colour (visual): white to off white
Appearance of substance (visual): powder
Colour index (0,5 M in DMF): ≤ 150 Hazen
Identity (IR): passes test
Enantiomeric purity: ≥ 99.8 % (a/a)
Purity (HPLC): ≥ 99.0 % (a/a)
Fmoc-ß-Ala-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-ß-Ala-Val-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Val-Val-OH (HPLC): ≤ 0.1 % (a/a)
Assay free amino acid (GC): ≤ 0.2 %
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (25 mmole in 50 ml DMF): clearly soluble
Assay (acidimetric): ≥ 98.0 %
Water (K. F.): ≤ 2.0 %
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.02 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Informações legais

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable