681664

Wnt Agonist I in DMSO

The Wnt Agonist I in DMSO, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

• Sinônimo(s): Wnt Agonist I in DMSO, 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I in DMSO, Wnt Pathway Activator I in DMSO, 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine
• Fórmula empírica (Notação de Hill): C₁₉H₁₈N₄O₃
• Número CAS: 853220-52-7
• Peso molecular: 350.37
• Número MDL: MFCD09908087
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• forma: liquid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• Condições de expedição: ambient
• temperatura de armazenamento: −70°C
• cadeia de caracteres SMILES: NC1=NC(NCC2=CC=C(OCO3)C3=C2)=CC(C4=CC=CC(OC)=C4)=N1
• InChI: 1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)
• chave InChI: FABQUVYDAXWUQP-UHFFFAOYSA-N

Descrição

Descrição geral

A cell-permeable, potent, and selective activator of Wnt signaling that does not inhibit the activity of GSK-3β (IC₅₀ >60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC₅₀ = 700 nM in HEK-293T cells). Reported to cause substantial head defects during Xenopus embryonic development. The solid form of this compound (Cat. No. 681665) is also available.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Reversible: yes

Embalagem

Packaged under inert gas

Advertência

Toxicity: Irritant (B)

forma física

A 25 mM (2 mg/228 µL) solution of Wnt Agonist I (Cat. No. 681665) in DMSO.

Reconstituição

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Outras notas

Liu, J., et al. 2005. Angew. Chem. Int. Ed.44, 1987.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable