528245

PLD Inhibitor, FIPI

The PLD Inhibitor, FIPI controls the biological activity of PLD. This small molecule/inhibitor is primarily used for Membrane applications.

• Sinônimo(s): PLD Inhibitor, FIPI, Compound 4k, PLD Inhibitor I
• Fórmula empírica (Notação de Hill): C₂₃H₂₄FN₅O₂
• Número CAS: 939055-18-2
• Peso molecular: 421.47
• Número MDL: MFCD18382115
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥99% (HPLC)
• forma: powder
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: off-white
• solubilidade: DMSO: 100 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C(C1=CC2=C(C=CC(F)=C2)N1)NCCN3CCC(N4C(NC5=C4C=CC=C5)=O)CC3

Descrição

Descrição geral

A cell-permeable, PLD1/2 inhibitor (IC₅₀ = 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC₅₀ = 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. It is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM. Unlike 1-butanol, this compound does not affect glucose-stimulated insulin secretion in Min6 pancreatic β-cells.

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Outras notas

Su, W., et al. 2009. Mol Pharmacol75, 437.
Monovich, L., et al. 2007. Bioorg Med Chem17, 2310.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable