422711-M

KN-93, Water-Soluble

This KN-93 is a water-soluble version of KN-93 that acts as a reversible and competitive inhibitor of CaM kinase II (K_i = 370 nM for rat brain).

• Sinônimo(s): KN-93, Water-Soluble
• Fórmula empírica (Notação de Hill): C₂₆H₂₉ClN₂O₄S · xH₃PO₄
• Peso molecular: 501.04
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic); protect from light
• cor: white
• solubilidade: water: 5 mg/mL
• temperatura de armazenamento: 2-8°C

Descrição

Descrição geral

Also available as a 5 mM solution in H₂O(Cat. No. 508315).

A water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A activity. Induces G₁ cell cycle arrest and apoptosis in NIH 3T3 cells.

Ações bioquímicas/fisiológicas

Primary Target
Calmodulin-Dependent Protein Kinase (CaM Kinase) 2

Target K_i: 370 nM for cam kinase 2

Advertência

Toxicity: Irritant (B)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Tombes, R.M., et al. 1995. Cell Growth Differ.6, 1063.
Chen, C., et al. 1994. Science266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun.195, 608.
Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun.191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable