420210

Jervine

A cell-permeable steroidal alkaloid similar to cyclopamine that displays teratogenic effects and induces cyclopia by blocking Sonic Hedgehog signaling.

• Sinônimo(s): Jervine, (3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one, 11-Ketocyclopamine, Shh Signaling Antagonist III
• Fórmula empírica (Notação de Hill): C₂₇H₃₉NO₃
• Número CAS: 469-59-0
• Peso molecular: 425.60
• Número MDL: MFCD01684066
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze
• cor: off-white
• solubilidade: ethanol: 10 mg/mL; DMSO: 5 mg/mL
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• InChI: 1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3
• chave InChI: CLEXYFLHGFJONT-UHFFFAOYSA-N

Descrição

Descrição geral

A cell-permeable steroidal alkaloid similar to cyclopamine (Cat. No. 239803) that displays teratogenic effects and induces cyclopia by blocking shh (Sonic Hedgehog) signaling (IC₅₀ = ~ 500-700 nM in s12 cells). Tomatidine (Cat. No. 614350) serves as a suitable negative control.

A cell-permeable steroidal alkaloid similar to cyclopamine (Cat. No. 239803) that displays teratogenic effects and induces cyclopia by blocking shh (Sonic Hedgehog) signaling (IC₅₀ ~500-700 nM in s12 cells). Tomatidine (Cat. No. 614350) serves as a suitable negative control.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
Induces cyclopia by blocking shh (Sonic Hedgehog) signaling

Product does not compete with ATP.

Reversible: no

Target IC₅₀: ~ 500-700 nM blocking shh (Sonic Hedgehog) signaling in s12 cells

Embalagem

Packaged under inert gas

Advertência

Toxicity: Toxic (F)

Nota de preparo

Slight warming may be required to achieve complete solubilization in ethanol.

Reconstituição

Following reconstitution in fresh DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Williams, J.A., et al. 2003. Proc. Natl. Acad. Sci. USA100, 4616.
Cooper, M. K., et al. 2003. Nat. Genet.33, 508.
Mistretta, C.M., 2003. Dev. Biol.254, 1.
ten Berge, D., et al. 2001. Development128, 2929.
Cooper, M.K., et al. 1998. Science280, 1603.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H301,H360D
• Declarações de precaução: P201 - P202 - P264 - P270 - P280 - P301 + P310
• Classificações de perigo: Acute Tox. 3 Oral - Repr. 1B
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable