05-502
Anti-FRS2/SNT-1 Antibody
Upstate®, from mouse
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
fonte biológica
mouse
Nível de qualidade
forma do anticorpo
purified antibody
tipo de produto de anticorpo
primary antibodies
clone
monoclonal
reatividade de espécies
rat, human
fabricante/nome comercial
Upstate®
técnica(s)
immunoprecipitation (IP): suitable
western blot: suitable
Isotipo
IgG
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... FRS2(10818)
Especificidade
FRS2/SNT-1 in unstimulated cells and phosphorylated FRS2/SNT-1 in NGF-stimulated cells
Imunogênio
Peptide corresponding to residues 283-297 of human FRS2/SNT-1
Aplicação
Detect FRS2/SNT-1 using this Anti-FRS2/SNT-1 Antibody validated for use in IP & WB.
Research Category
Signaling
Signaling
Research Sub Category
Developmental Signaling
Developmental Signaling
Qualidade
routinely evaluated by immunoprecipitating FRS2/SNT-1 from NGF-stimulated and unstimulated rat PC-12 RIPA cell lysates, subsequently immunoblotted with the same antibody.
Descrição-alvo
non-phosphorylated (68kDa) and phosphorylated (83kDa)
forma física
0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide containing 30% glycerol
Format: Purified
Protein G Chromatography
Armazenamento e estabilidade
2 years at -20°C
Informações legais
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Certificados de análise (COA)
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Human fibroblast growth factor receptor 1-IIIb is a functional fibroblast growth factor receptor expressed in the pancreas and involved in proliferation and movement of pancreatic ductal cells.
Zhanbing Liu, Toshiyuki Ishiwata, Shaxia Zhou, Susanne Maier, Doris Henne-Bruns et al.
Pancreas null
S O Meakin et al.
The Journal of biological chemistry, 274(14), 9861-9870 (1999-03-27)
We have isolated a human cDNA for the signaling adapter molecule FRS-2/suc1-associated neurotrophic factor target and shown that it is tyrosine-phosphorylated in response to nerve growth factor (NGF) stimulation. Importantly, we demonstrate that the phosphotyrosine binding domain of FRS-2 directly
Y R Hadari et al.
Molecular and cellular biology, 18(7), 3966-3973 (1998-06-25)
FRS2 is a lipid-anchored docking protein that plays an important role in linking fibroblast growth factor (FGF) and nerve growth factor receptors with the Ras/mitogen-activated protein (MAP) kinase signaling pathway. In this report, we demonstrate that FRS2 forms a complex
H Xu et al.
The Journal of biological chemistry, 273(29), 17987-17990 (1998-07-11)
Fibroblast growth factors (FGFs) stimulate tyrosine phosphorylation of a membrane-anchored adapter protein, FRS2/SNT-1, promoting its association with Shp-2 tyrosine phosphatase and upstream activators of Ras. Using the yeast two-hybrid protein-protein interaction assay, we show that FRS2/SNT-1 and a newly isolated
Vito Guagnano et al.
Cancer discovery, 2(12), 1118-1133 (2012-09-25)
Patient stratification biomarkers that enable the translation of cancer genetic knowledge into clinical use are essential for the successful and rapid development of emerging targeted anticancer therapeutics. Here, we describe the identification of patient stratification biomarkers for NVP-BGJ398, a novel
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