05-23-2101

Vasoactive Intestinal Peptide, Human, Porcine, and Rat

Acts as a mitogenic factor for embryonic neurons in the sympathetic nervous system.

• Sinônimo(s): Vasoactive Intestinal Peptide, Human, Porcine, and Rat, VIP
• Fórmula empírica (Notação de Hill): C₁₄₇H₂₃₈N₄₄O₄₂S
• Número CAS: 40077-57-4
• Peso molecular: 3325.80
• Número MDL: MFCD00167535
• Código UNSPSC: 12352202
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• forma: lyophilized solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic)
• cor: white to off-white
• solubilidade: 5% acetic acid: 1 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• InChI: 1S/C147H237N43O43S/c1-18-75(12)115(142(229)180-96(56-72(6)7)131(218)183-104(145(232)233)63-110(155)200)188-139(226)106(68-192)185-134(221)101(62-109(154)199)177-130(217)95(55-71(4)5)174-132(219)97(58-81-37-41-84(195)42-38-81)175-125(212)88(33-23-26-49-149)167-123(210)89(34-24-27-50-150)171-140(227)113(73(8)9)186-118(205)76(13)164-121(208)93(47-53-234-17)170-127(214)92(45-46-107(152)197)169-122(209)87(32-22-25-48-148)166-124(211)90(35-28-51-161-146(156)157)168-129(216)94(54-70(2)3)173-126(213)91(36-29-52-162-147(158)159)172-143(230)116(78(15)193)189-136(223)98(59-82-39-43-85(196)44-40-82)176-133(220)100(61-108(153)198)178-135(222)103(65-112(203)204)182-144(231)117(79(16)194)190-137(224)99(57-80-30-20-19-21-31-80)181-141(228)114(74(10)11)187-119(206)77(14)165-128(215)102(64-111(201)202)179-138(225)105(67-191)184-120(207)86(151)60-83-66-160-69-163-83/h19-21,30-31,37-44,66,69-79,86-106,113-117,191-196H,18,22-29,32-36,45-65,67-68,148-151H2,1-17H3,(H2,152,197)(H2,153,198)(H2,154,199)(H2,155,200)(H,160,163)(H,164,208)(H,165,215)(H,166,211)(H,167,210)(H,168,216)(H,169,209)(H,170,214)(H,171,227)(H,172,230)(H,173,213)(H,174,219)(H,175,212)(H,176,220)(H,177,217)(H,178,222)(H,179,225)(H,180,229)(H,181,228)(H,182,231)(H,183,218)(H,184,207)(H,185,221)(H,186,205)(H,187,206)(H,188,226)(H,189,223)(H,190,224)(H,201,202)(H,203,204)(H,232,233)(H4,156,157,161)(H4,158,159,162)/t75-,76-,77-,78+,79+,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,113-,114-,115-,116-,117-/m0/s1
• chave InChI: VBUWHHLIZKOSMS-RIWXPGAOSA-N

Descrição

Descrição geral

Acts as a mitogenic factor for embryonic neurons in the sympathetic nervous system. Has powerful hypotensive and vasodilatory effects. Behaves either as a circulating hormone or as a neurotransmitter. Stimulates cAMP production in rat peritoneal macrophages. Inhibits the growth of human small-cell lung carcinoma (SCLC) both in vitro and in vivo, suggesting that it may be useful as a less toxic alternative to conventional chemotherapeutic agents in the treatment of SCLC. Nitric oxide stimulates the release of this peptide.

Acts as a mitogenic factor for embryonic neurons in the sympathetic nervous system. Has powerful hypotensive and vasodilatory effects. Behaves either as a circulating hormone or as a neurotransmitter. Stimulates cAMP production in rat peritoneal macrophages. Nitric oxide stimulates the release of this peptide. Inhibits human small-cell lung carcinoma (SCLC) in nude mice both in vitro and in vivo, suggesting that it may be useful as a less toxic alternative to conventional chemotherapeutic agents in the treatment of SCLC.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
Mitogenic factor for embryonic neurons

Product does not compete with ATP.

Reversible: no

Embalagem

Yes

Advertência

Toxicity: Harmful (C)

Sequência

H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂

forma física

Supplied as a trifluoroacetate salt.

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Maruno, K., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14373.
Bakker, R., et al. 1993. Am. J. Physiol.264, R362.
Grider, J.R. 1993. Am. J. Physiol.264, G334.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable