04-1551

Anti-SMRT Antibody, clone 1SM-1E7

ascites fluid, clone 1SM-1E7, from mouse

• Sinônimo(s): CTG repeat protein 26, Silencing mediator of retinoic acid and thyroid hormone receptor, T3 receptor-associating factor, Thyroid-, retinoic-acid-receptor-associated corepressor, nuclear receptor co-repressor 2, silencing mediator for retinoid and thyroid
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• forma do anticorpo: ascites fluid
• tipo de produto de anticorpo: primary antibodies
• clone: 1SM-1E7, monoclonal
• reatividade de espécies: mouse, rat, human
• técnica(s): western blot: suitable
• Isotipo: IgG2aκ
• nº de adesão NCBI: NP_001070729.1
• nº de adesão UniProt: Q9Y618
• Condições de expedição: dry ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... NCOR2(9612) , TRAC(28755)

Descrição

Descrição geral

The Silencing mediator of retinoic acid & thyroid hormone receptor protein, commonly called the SMRT protein mediates the transcriptional repression of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription machinery. Consistent with this activity, this protein is known to form a large corepressor complex containing SIN3A/B and histone deacetylases HDAC1 and HDAC2. SMRT is also a component of the N-Cor repressor (nuclear receptor corepressor), a multi-subunit complex minimally composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. SMRT and nuclear receptor corepressor N-CoR are related transcriptional corepressors which contain two distinct domains capable of interacting with unliganded nuclear receptors to repress their basal transcriptional activity.

Especificidade

This antibody recognizes SMRT.

Aplicação

Use Anti-SMRT Antibody, clone 1SM-1E7 (Mouse Monoclonal Antibody) validated in WB to detect SMRT also known as CTG repeat protein 26, Silencing mediator of retinoic acid & thyroid hormone receptor.

Qualidade

Evaluated by Western Blot in human brain lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected SMRT on 10 µg of human brain lysate.

Descrição-alvo

~ 275 kDa

forma física

Unpurified mouse monoclonal IgG2aκ ascites with 0.05% sodium azide.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): nwg
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable