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H-076

Supelco

9-Hydroxyrisperidone solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (Notação de Hill):
C23H27FN4O3
Número CAS:
144598-75-4
Peso molecular:
426.48
Código UNSPSC:
41116107
NACRES:
NA.24

grau

certified reference material

forma

liquid

Características

Snap-N-Spike®/Snap-N-Shoot®

embalagem

ampule of 1 mL

fabricante/nome comercial

Cerilliant®

concentração

1.0 mg/mL in methanol

técnica(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicação(ões)

clinical testing

formato

single component solution

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCC(O)C5=N1

InChI

1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3

chave InChI

PMXMIIMHBWHSKN-UHFFFAOYSA-N

Informações sobre genes

human ... DRD2(1813) , HTR2A(3356)

Categorias relacionadas

Descrição geral

A Snap-N-Spike® Reference Solution suitable to use in LC/MS or GC/MS applications for urine drug testing, clinical toxicology, and forensic analysis. Also known as paliperidone, 9-Hydroxyrisperidone is sold under the brand name Invega, an atypical antipsychotic used for acute and maintenance treatment of schizophrenia. The drug is also the primary metabolite of risperidone, marketed as the atypical antipsychotic Risperdal®.

Aplicação


  • 9-HydroxyrisperiDonesolution for in vitro research: Employed in pharmacological studies to investigate dual antipsychotic therapies in treatment-resistant conditions, enhancing the understanding of drug interactions and efficacy (Warnick et al., 2024).

  • High-purity 9-HydroxyrisperiDoneliquid for pharmacological studies: Utilized in crystallography research to assess the impact of alkyl chain length on the crystallization behavior of related compounds, providing insights into drug formulation strategies (Chen et al., 2024).

  • Buy 9-HydroxyrisperiDonesolution for receptor binding assays: Applied in the development of novel drug delivery systems such as dissolving microneedles, enhancing the administration of long-acting antipsychotic treatments (Londhe and Bhadale, 2023).

  • 9-HydroxyrisperiDoneactive metabolite for antipsychotic research: Analyzed in postmortem toxicological assessments to identify metabolites, improving forensic analysis techniques and therapeutic drug monitoring (Yamagishi et al., 2023).

  • Analytical standard 9-HydroxyrisperiDonefor biochemistry labs: Investigated in the synthesis of prodrug microcrystals for extended-release formulations, aiding in the design of more effective and patient-friendly antipsychotic medications (Xu et al., 2022).




Informações legais

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Risperdal is a registered trademark of Johnson & Johnson
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órgãos-alvo

Eyes

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

49.5 °F - closed cup

Ponto de fulgor (°C)

9.7 °C - closed cup

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Drug and therapeutics bulletin, 50(9), 102-105 (2012-09-12)
For over 40 years, antipsychotic drugs have been used as long-term maintenance treatment to control symptoms and reduce relapse rates in patients with schizophrenia. 'First-generation' oral agents such as haloperidol and chlorpromazine are associated with high levels of unwanted neurological
Caroline M Perry
Paediatric drugs, 14(6), 417-427 (2012-10-12)
Paliperidone, the major active metabolite of risperidone, is an atypical antipsychotic agent formulated as an extended-release (ER) tablet suitable for once-daily oral administration. Paliperidone ER is approved for the treatment of adolescents aged 12-17 years with schizophrenia in the US
Pierre S Chue et al.
Expert review of neurotherapeutics, 12(12), 1399-1410 (2012-12-15)
Paliperidone, or 9-hydroxyrisperidone (Invega(®), Janssen, Antwerp, Belgium) is the major active metabolite of the atypical antipsychotic risperidone (Risperdal(®), Janssen). It possesses a similar, though not identical, receptor pharmacology to the parent molecule. There are additional differences in terms of its
Yvette Roke et al.
Journal of child and adolescent psychopharmacology, 22(6), 432-439 (2012-12-14)
The aim of this study was to investigate the long-term treatment effects of risperidone on prolactin levels and prolactin-related side effects in pubertal boys with autism spectrum disorders (ASD) and disruptive behavior disorders (DBD). Physical healthy 10-20-year-old males with ASD
Treating residual insomnia in schizophrenia: examining the options.
C Andrade et al.
Acta psychiatrica Scandinavica, 127(1), 11-11 (2012-12-18)
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