901376

Polyester bis-MPA dendron

no. Surface Groups 8, 8 acetylene, 1 NHBoc (core), generation 3

• Sinônimo(s): PFd-G3-BOCNH-Acetylene, bis-MPA dendron
• Fórmula empírica (Notação de Hill): C₁₀₇H₁₃₅NO₅₃
• Peso molecular: 2283.19
• Código UNSPSC: 12162002
• NACRES: NA.23

Propriedades

• Nível de qualidade: 100
• Formulário: solid
• peso molecular: generation 3
• Nº de grupos de superfície: 8
• cor: white to off-white
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

• Polymer architecture: Dendron
• Generation: 3
• Core functional group: Boc-protected amine
• End Group Functionality: Alkyne
• No. Surface Groups: 8
• Calculated Mol. Wt.: 2283.21 g/mol
• Boc : tert-Butyloxycarbonyl
• bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid

Polyester bis-MPA dendron (8 acetylene, 1 NHBoc (core), generation 3), a high generation dendron, is synthesized by using anhydride activated bis-MPA monomers via divergent growth. It has a large and exact number of reactive groups and has dual functionalization capacity that makes it useful as a high-value scaffold.

Aplicação

Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. These alkyne-functionalized dendrimers can be readily functionalized using either copper(I)-catalysed alkyne-azide cycloaddition (CuAAC), strain-promoted alkyne-azide cycloaddition (SPAAC), or thiol-yne click reactions. Additionally, the amine-functionalized core can be readily used in EDC or DCC coupling reactions (after Boc deprotection) with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable