802255

8-Amino-5-methoxyquinoline

95%

• Sinônimo(s): 5-Methoxy-8-quinolinamine, Chen Auxilliary, MQ, Gong Chen Auxiliary, MQ Auxiliary
• Fórmula empírica (Notação de Hill): C₁₀H₁₀N₂O
• Número CAS: 30465-68-0
• Peso molecular: 174.20
• Número MDL: MFCD01593679
• Código UNSPSC: 12352100
• ID de substância PubChem: 329768733
• NACRES: NA.22

Propriedades

• Nível de qualidade: 100
• Ensaio: 95%
• forma: powder
• pf: 90-95 °C
• cadeia de caracteres SMILES: NC1=CC=C(OC)C2=CC=CN=C21
• InChI: 1S/C10H10N2O/c1-13-9-5-4-8(11)10-7(9)3-2-6-12-10/h2-6H,11H2,1H3
• chave InChI: MFLLTRMMFHENCM-UHFFFAOYSA-N

Descrição

Descrição geral

8-Amino-5-methoxyquinoline is a substituted quinoline derivative that can be prepared using 5-chloro-2-nitroaniline as a starting material. It can act as an easily removable directing group and also mediate C-H activation. These properties have been useful for synthesizing isomeric dibenzoxazepinones and complex pyrrolidinones from compounds containing 8-amino-5-methoxyquinoline moiety.

Aplicação

The Chen auxiliary was reported to be an effective directing group in the synthesis of pyrrolidones from assisting in the activation of C(sp³)-H bonds and can be readily installed through amide bond formation and removed through mild conditions using CAN at room temperature.

Outras notas

Use of a Readily Removable Auxiliary Group for the Synthesis of Pyrrolidones by the Palladium-Catalyzed Intramolecular Amination of Unactivated γ C(sp³)-H bonds

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable