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Merck
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Documentos Principais

246298

Sigma-Aldrich

4-Methoxyindole

99%

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About This Item

Fórmula empírica (Notação de Hill):
C9H9NO
Número CAS:
Peso molecular:
147.17
Número MDL:
Código UNSPSC:
12352100
ID de substância PubChem:
NACRES:
NA.22

Nível de qualidade

Ensaio

99%

Formulário

powder

p.e.

181-183 °C/24 mmHg (lit.)

pf

69-70 °C (lit.)

solubilidade

ethanol: 50 mg/mL, clear, faintly yellow

cadeia de caracteres SMILES

COc1cccc2[nH]ccc12

InChI

1S/C9H9NO/c1-11-9-4-2-3-8-7(9)5-6-10-8/h2-6,10H,1H3

chave InChI

LUNOXNMCFPFPMO-UHFFFAOYSA-N

Aplicação

4-Methoxyindole was used for comparing the complexation reaction of β-cyclodextrin (β-CD) with pindolol using reversed-phase liquid chromatography.
Reactant for preparation of:
  • GABA analogs
  • Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes
  • Anticancer agents
  • Integrase strand-transfer inhibitors (INSTIs)
  • Inhibitor of Proliferation of Colon Cancer Cells
  • Isomeridianin G as GSK-3ß inhibitors
  • HIV-1 integrase inhibitors
  • Inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves


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Carmen Gazpio et al.
Journal of pharmaceutical and biomedical analysis, 37(3), 487-492 (2005-03-03)
The complexation with beta-cyclodextrin (beta-CD) has been investigated using reversed-phase liquid chromatography. The compounds tested have been pindolol and, for comparison purposes, indole and 4-methoxyindole. The retention behaviour has been analysed on a Kromasil 100 C18 column and the mobile
Brenden Barco et al.
Nature communications, 10(1), 3444-3444 (2019-08-03)
Plants synthesize numerous ecologically specialized, lineage-specific metabolites through biosynthetic gene duplication and functional specialization. However, it remains unclear how duplicated genes are wired into existing regulatory networks. We show that the duplicated gene CYP82C2 has been recruited into the WRKY33 regulon
Thomas Heine et al.
Applied biochemistry and biotechnology, 181(4), 1590-1610 (2016-11-11)
The enantioselective epoxidation of styrene and related compounds by two-component styrene monooxygenases (SMOs) has targeted these enzymes for development as biocatalysts. In the present work, we prepare genetically engineered fusion proteins that join the C-terminus of the epoxidase (StyA) to
Jung Min Song et al.
International journal of pharmaceutics, 477(1-2), 96-101 (2014-10-15)
Indole-3-carbinol (I3C), a constituent of commonly consumed Brassica vegetables, has been shown to have anticancer effects in a variety of preclinical models of lung cancer. However, it has shown only limited efficacy in clinical trials, likely due to its poor
Tien-Yuan Wu et al.
Journal of pharmacokinetics and pharmacodynamics, 42(4), 401-408 (2015-07-04)
3,3'-Diindolylmethane (DIM) has been investigated as a potential anti-cancer chemopreventive agent in many preclinical and clinical studies. In this study, we sought to characterize the pharmacokinetics of DIM and to build a pharmacokinetic (PK) and pharmacodynamic (PD) model of the

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