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Merck

CASP5

caspase 5, apoptosis-related cysteine peptidase

Sinônimos:
ICE(rel)III, ICEREL-III, ICH-3
Espécies:
Human CASP5 (838)
ID UniProtKB:
P51878, B4DKP5, Q0QVY7, Q0QVY8, Q0QVZ0, Q0QVZ1, Q0QVZ2, Q14DD6
ID do gene:
  • Human(838) Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]

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Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
HPA040937
Anti-CASP5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunohistochemistry
ABS445
Anti-Caspase-5 Antibody, from rabbit, purified by affinity chromatography,
Reatividade de espécies
human
Aplicação
immunocytochemistry
immunofluorescence
western blot
PRS3455
Anti-Caspase-5 (ab1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Reatividade de espécies
human
Aplicação
ELISA
western blot
SAB4503304
Anti-CASP5 (p10, Cleaved-Ser331) antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
human
Aplicação
ELISA
western blot

Proteins

Número do produto
Descrição
Espécies
C6482
Caspase 5 human, recombinant, expressed in E. coli, 5,000 units/mg protein,
Espécies
human

esiRNA

Número do produto
Descrição
Espécies
EHU127011
MISSION® esiRNA, targeting human CASP5,
Espécies
human