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Key Documents

A1300000

Ascorbic acid

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

L-Ascorbic acid, L-Threoascorbic acid, Antiscorbutic factor, Vitamin C

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About This Item

Empirical Formula (Hill Notation):
C6H8O6
CAS Number:
Molecular Weight:
176.12
Beilstein:
84272
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

biological source

synthetic

grade

pharmaceutical primary standard

Agency

EP Reference standard

API family

ascorbic acid

form

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

190-194 °C (dec.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

InChI key

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ascorbic EP reference standard, intended for use only as specifically prescribed in the European Pharmacopoeia. Also used for the determination of the analyte in pharmaceutical formulations by chromatography and spectrophotometric techniques.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Ascorbic acid
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 18(6), 6868-6869 (2019)
Reversed-phase ion-pair HPLC determination of some water-soluble vitamins in pharmaceuticals
Ivanovic D, et al.
Journal of Pharmaceutical and Biomedical Analysis, 18(6), 999-1004 (1999)
Spectrophotometric determination of L-ascorbic acid in pharmaceuticals
Szpikowska-Sroka B and Poledniok J
Journal of Analytical Chemistry, 66(10), 941-941 (2011)
Vitamin C: One compound, several uses. Advances for delivery, efficiency and stability
Carita AC, et al.
Nanomedicine: Nanotechnology, Biology, and Medicine, 31(2), 102117-102117 (2019)
Vitamin c
Linster CL and Van SE
FEBS Journal, 274(1), 1-22 (2007)

Protocols

Separation of (L)-Dehydroascorbic acid; L-Ascorbic acid 20 μg/mL

Separation of Pyridoxine; Nicotinamide; Nicotinic acid; Folic acid; (−)-Riboflavin, meets USP testing specifications; L-Ascorbic acid

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