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Key Documents

934321

Sigma-Aldrich

L-Valyl-L-citrulline

≥95%

Synonym(s):

L-Valyl-N5-(aminocarbonyl)-L-ornithine, Val-Cit

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About This Item

Empirical Formula (Hill Notation):
C11H22N4O4
CAS Number:
159858-33-0
Molecular Weight:
274.32
UNSPSC Code:
12352209
NACRES:
NA.21

Quality Level

100

Assay

≥95%

form

powder or crystals

color

off-white to light yellow

storage temp.

2-8°C

Application

This is a cathepsin cleavable linker used in the construction of antibody drug conjugates (ADC & Bioconjugation).

Features and Benefits

Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). The Val-Cit is specifically cleaved by cathepsin B. The Boc group can be deprotected under acidic conditions to generate a free amine group. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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