SML2221
CU-CPT9a
≥98% (HPLC)
Synonym(s):
2-Methyl-4-(7-methoxyl-4-quinolinyl)-phenol, Phenol, 4-(7-methoxy-4-quinolinyl)-2-methyl
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About This Item
Empirical Formula (Hill Notation):
C17H15NO2
CAS Number:
Molecular Weight:
265.31
UNSPSC Code:
12352200
NACRES:
NA.77
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
CC1=CC(C2=CC=NC3=CC(OC)=CC=C23)=CC=C1O
Biochem/physiol Actions
CU-CPT9a is a potent and selective inhibitor of Toll-like receptor 8 (TLR8). It binds to TLR8 at a site different from current small-molecule TLR7/8 agonists, stabilizing the TLR8 dimer in its resting state, thus preventing TLR8 activation It exhibited an IC50 value of 0.5 nM and blocked TLR8 activation induced by either resiquimod (R848) or ssRNA without affecting the closely related TLR7 or cells expressing other TLRs. CU-CPT9a also suppressed TNF-α levels in a dose-dependent manner in cells from patients with rheumatoid arthritis.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Shuting Zhang et al.
Nature chemical biology, 14(1), 58-64 (2017-11-21)
Endosomal Toll-like receptors (TLR3, TLR7, TLR8, and TLR9) are highly analogous sensors for various viral or bacterial RNA and DNA molecular patterns. Nonetheless, few small molecules can selectively modulate these TLRs. In this manuscript, we identified the first human TLR8-specific
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