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1123000

USP

Chlorpheniramine maleate

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

(±)-Chlorpheniramine maleate salt

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About This Item

Formule empirique (notation de Hill):
C16H19ClN2 · C4H4O4
Numéro CAS:
113-92-8
Poids moléculaire :
390.86
Numéro MDL:
MFCD00069225
Code UNSPSC :
41116107
ID de substance PubChem :
329749337
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

chlorpheniramine

Fabricant/nom de marque

USP

Pf

130-135 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O

InChI

1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

Clé InChI

DBAKFASWICGISY-BTJKTKAUSA-N

Informations sur le gène

human ... HRH1(3269)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Chlorpheniramine maleate USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Chlorpheniramine Maleate Tablets
  • Chlorpheniramine Maleate Oral Solution
  • Chlorpheniramine Maleate Extended-Release Capsules
  • Chlorpheniramine Maleate and Pseudoephedrine Hydrochloride Oral Solution
  • Acetaminophen, Chlorpheniramine Maleate, and Dextromethorphan Hydrobromide Tablets
  • Chlorpheniramine Maleate and Pseudoephedrine Hydrochloride Extended-Release Capsules
  • Penicillin G Procaine, Dihydrostreptomycin Sulfate, Chlorpheniramine Maleate, and Dexamethasone Injectable Suspension

Actions biochimiques/physiologiques

H1 Histamine receptor antagonist.

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

C1800000

Chlorphenamine maleate, European Pharmacopoeia (EP) Reference Standard

Y0000436

Chlorphenamine impurity A, European Pharmacopoeia (EP) Reference Standard

Y0000437

Chlorphenamine impurity C, European Pharmacopoeia (EP) Reference Standard

1123135

Chlorpheniramine Related Compound B, United States Pharmacopeia (USP) Reference Standard

1123146

Chlorpheniramine Related Compound C, United States Pharmacopeia (USP) Reference Standard

38595

α-(4-Chlorophenyl)-α-[2-(dimethylamino)ethyl]-2-pyridineacetonitrile hydrochloride, pharmaceutical impurity standard

PHR1647

Chlorpheniramine Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1688

Chlorpheniramine Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2004

Chlorpheniramine Impurity A, Pharmaceutical Secondary Standard; Certified Reference Material

BP081

Chlorphenamine maleate, British Pharmacopoeia (BP) Reference Standard

PHR2103

Chlorphenamine Impurity D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2104

2-(4-Chlorophenyl)-4-dimethylaminobutyronitrile hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2105

Chlorphenamine N-Oxide Maleate, Pharmaceutical Secondary Standard; Certified Reference Material

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Conseils de prudence

P301 + P312 + P330

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Chlorpheniramine Related Compound B

vibrant-m

P0850000

Pheniramine maleate

vibrant-m

Y0000436

Chlorphenamine impurity A

Acétaminophène United States Pharmacopeia (USP) Reference Standard

USP

1003009

Acétaminophène

Guaifenesin United States Pharmacopeia (USP) Reference Standard

USP

1301007

Guaifenesin

vibrant-m

Y0001170

Ascorbic acid impurity D

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Y0001024

Ascorbic acid impurity C

4-Aminophénol United States Pharmacopeia (USP) Reference Standard

USP

1021204

4-Aminophénol

USP

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1495005

Papain

L Canto-de-Souza et al.
Neuroscience letters, 587, 11-16 (2014-12-20)
Several findings have pointed to the role of histaminergic neurotransmission in the modulation of anxiety-like behaviors and emotional memory. The elevated plus-maze (EPM) test has been widely used to investigate the process of anxiety and also has been used to
Cheryl C Y Loh et al.
PloS one, 9(10), e110800-e110800 (2014-10-25)
Chloroquine was a cheap, extremely effective drug against Plasmodium falciparum until resistance arose. One approach to reversing resistance is the inhibition of chloroquine efflux from its site of action, the parasite digestive vacuole. Chloroquine accumulation studies have traditionally relied on
Hao Lou et al.
Drug development and industrial pharmacy, 40(7), 910-918 (2013-04-30)
To mask the bitterness of Chlorpheniramine Maleate via encapsulating drug into Eudragit EPO microparticles, and then incorporate these microparticles into orally disintegrating films (ODF) and orally disintegrating tablets (ODT) for pediatric uses. Spray drying of water-in-oil emulsion was utilized to
Shigeru Hishinuma et al.
Biochemical pharmacology, 91(2), 231-241 (2014-07-30)
Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human

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