1045520

Azacitidine

United States Pharmacopeia (USP) Reference Standard

• Synonyme(s) : 5-Azacytidine, 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, Ladakamycin
• Formule empirique (notation de Hill): C₈H₁₂N₄O₅
• Numéro CAS: 320-67-2
• Poids moléculaire : 244.20
• Numéro Beilstein : 620461
• Numéro MDL: MFCD00006539
• Code UNSPSC : 41116107
• ID de substance PubChem : 329749084
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: pharmaceutical primary standard
• Famille d'API: azacitidine
• Fabricant/nom de marque: USP
• Pf: 226-232 °C (dec.) (lit.)
• Application(s): pharmaceutical (small molecule)
• Format: neat
• Chaîne SMILES: NC1=NC(=O)N(C=N1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
• InChI: 1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
• Clé InChI: NMUSYJAQQFHJEW-KVTDHHQDSA-N
• Informations sur le gène: human ... DNMT1(1786) , DNMT3A(1788)

Description

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Azacitidine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Actions biochimiques/physiologiques

A potent growth inhibitor and cytotoxic agent; inhibits DNA methyltransferase, an important regulatory mechanism of gene expression, gene activation and silencing.

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS08,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H302 - H341 - H350 - H360FD - H372 - H410
• Conseils de prudence: P202 - P260 - P264 - P273 - P301 + P312 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 1A - Muta. 2 - Repr. 1B - STOT RE 1
• Code de la classe de stockage: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3