BP1234

Letrozole

British Pharmacopoeia (BP) Reference Standard

• Synonyme(s) : 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
• Formule empirique (notation de Hill): C₁₇H₁₁N₅
• Numéro CAS: 112809-51-5
• Poids moléculaire : 285.30
• Numéro MDL: MFCD00866241
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: pharmaceutical primary standard
• Niveau de qualité: 100
• Famille d'API: letrozole
• Forme: powder
• Durée de conservation: limited shelf life, expiry date on the label
• Fabricant/nom de marque: BP
• Application(s): pharmaceutical; pharmaceutical small molecule
• Format: neat
• Température de stockage: 2-8°C
• Chaîne SMILES: N#CC(C=C1)=CC=C1C(N2C=NC=N2)C3=CC=C(C#N)C=C3
• InChI: 1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
• Clé InChI: HPJKCIUCZWXJDR-UHFFFAOYSA-N
• Informations sur le gène: human ... CYP19A1(1588)

Description

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Letrozole BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Letrozole Tablets

Actions biochimiques/physiologiques

Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues.

Conditionnement

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Autres remarques

Sales restrictions may apply.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H361fd,H373
• Conseils de prudence: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Repr. 2 - STOT RE 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable