569251-U

Discovery^® HS C18 (3 µm) HPLC Columns

L × I.D. 7.5 cm × 4.6 mm, HPLC Column

• Synonyme(s) : Discovery RP18 HPLC Column
• Code UNSPSC : 41115700
• eCl@ss : 32110501
• Nomenclature NACRES : SB.52

Propriétés

• product name: Colonne HPLC Discovery^® HS C18, 3 μm particle size, L × I.D. 7.5 cm × 4.6 mm
• Matériaux: stainless steel column
• Niveau de qualité: 100
• Agence: suitable for USP L1
• Gamme de produits: Discovery^®
• Caractéristiques: endcapped
• Fabricant/nom de marque: Discovery^®
• Conditionnement: 1 ea of
• Ampleur du marquage: 20% Carbon loading
• Paramètres: ≤70 °C temp. range; 400 bar pressure (5801 psi)
• Technique(s): HPLC: suitable; LC/MS: suitable
• L × D.I.: 7.5 cm × 4.6 mm
• Superficie: 300 m²/g
• Couverture de surface: 3.2 μmol/m²
• Impuretés: <10 ppm metals
• Matrice: silica gel, high purity, spherical particle platform; fully porous particle
• Groupe de la matrice active: C18 (octadecyl) phase
• Taille des particules: 3 μm
• Dimension de pores: 120 Å
• operating pH range: 2-8
• Application(s): food and beverages
• Technique de séparation: reversed phase

Description

Description générale

Discovery^® HS C18 HPLC column (L × I.D. 7.5 cm × 4.6 mm) is generally found to be stable under acidic and basic conditions.

Application

• A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies.: This research demonstrates the use of the Discovery^® HS C18 HPLC Column in developing a robust HPLC method for analyzing molnupiravir, showcasing its importance in current pandemic-related pharmaceutical research (Recber et al., 2022).


• A new RP-HPLC method as an auxiliary tool for optimization of sample preparation procedures for tracing of PPCPs of different hydrophilicities.: Highlights the adaptability of the Discovery^® HS C18 HPLC Column in environmental monitoring, specifically for pharmaceutical and personal care products, enhancing analytical methods for environmental safety (Portillo-Castillo et al., 2021).


• Analysis of terizidone in plasma using HPLC-UV method and its application in a pharmacokinetic study of patients with drug-resistant tuberculosis.: This study uses the Discovery^® HS C18 HPLC Column to assess terizidone levels in patient plasma, providing critical insights into the treatment of drug-resistant tuberculosis (Mulubwa and Mugabo, 2018).


• Optimization of LC method for the quantification of doxorubicin in plasma and urine samples in view of pharmacokinetic, biomedical and drug monitoring therapy studies.: Depicts the utility of the Discovery^® HS C18 HPLC Column in optimizing liquid chromatography methods for the potent chemotherapeutic agent doxorubicin, underscoring its role in therapeutic drug monitoring (Maliszewska et al., 2018).


• Universal efavirenz determination in transport study, rat placenta perfusion and placenta lysate by HPLC-UV.: Showcases the Discovery^® HS C18 HPLC Column′s application in studying the permeability and transport of efavirenz across the placenta, providing valuable pharmacological insights (Zelena et al., 2017).

Caractéristiques et avantages

• Stables, faible relargage pour applications LC-MS
• Changement d′échelle de l′analytique à la préparative
• Haute stabilité pour assurer une excellente reproductibilité d′injection à injection et de lot à lot
• Hydrophobicité plus élevée pour une meilleure résolution des analytes difficiles

   

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Informations légales

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable