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Z4250

Sigma-Aldrich

Zymosan A from Saccharomyces cerevisiae

for inducing inflamatory response

Synonyme(s) :

Yeast Cell Wall

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About This Item

Numéro CAS:
58856-93-2
Numéro MDL:
MFCD00082157
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.61

Source biologique

Saccharomyces cerevisiae

Niveau de qualité

200

Forme

powder with small lumps

Technique(s)

flow cytometry: suitable
tissue culture: suitable

Couleur

off-white to light brown

Température de stockage

2-8°C

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Application

  • in flow cytometry
  • to study its effect on head kidney leukocytes from rainbow trout (Oncorhynchus mykiss)

Zymosan A from Saccharomyces cerevisiae has been used:
  • as a positive control to determine the activation of complement cascade
  • for respiratory burst (RB) assay
  • to assess its effects on performance, immunity, heat shock protein and apoptosis related gene expressions of dairy cows under heat stress (HS)
  • a stimulating agent in Krebs-Ringer phosphate (KRP) medium
  • to induce thermal hyperalgesia in mice

Actions biochimiques/physiologiques

Zymosan is prepared from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action. Zymosan A, a 13 beta glucan contributes to the development of organic dust-induced respiratory disease.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Protective effects of zymosan on heat stress-induced immunosuppression and apoptosis in dairy cows and peripheral blood mononuclear cells
Sun Y, et al.
Cell Stress & Chaperones, 23(5), 1069-1078 (2018)
The G2A receptor controls polarization of macrophage by determining their localization within the inflamed tissue
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Frontiers in Immunology, 9, 2261-2261 (2018)
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Self-mineralizing Ca-enriched Methacrylated Gellan Gum Beads for Bone Tissue Engineering
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PLoS biology, 16(4), e2005504-e2005504 (2018-04-19)
The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2) responses, including those elicited by parasitic helminths, remain incompletely understood. Here, we report that soluble egg antigen (SEA) from Schistosoma mansoni, which is well known to drive
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