Z0167

Zearalanone

• Synonyme(s) : 2,4-Dihydroxy-6-(10-hydroxy-6-oxoundecyl)benzoic acid μ-lactone
• Formule empirique (notation de Hill): C₁₈H₂₄O₅
• Numéro CAS: 5975-78-0
• Poids moléculaire : 320.38
• Numéro MDL: MFCD00135821
• Code UNSPSC : 12352200
• ID de substance PubChem : 24902160
• Nomenclature NACRES : NA.77

Propriétés

• Stérilité: non-sterile
• Niveau de qualité: 200
• Essai: ≥98% (TLC)
• Forme: powder
• Solubilité: methanol: 9.80-10.20 mg/mL, clear, colorless
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: C[C@H]1CCCC(=O)CCCCCc2cc(O)cc(O)c2C(=O)O1
• InChI: 1S/C18H24O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h10-12,20-21H,2-9H2,1H3/t12-/m0/s1
• Clé InChI: APJDQUGPCJRQRJ-LBPRGKRZSA-N
• Informations sur le gène: rat ... Ar(24208)

Description

Description générale

Zearalanone (ZEA) or F-2 toxin, a nonsteroidal estrogenic mycotoxin is produced by various Fusarium species. Fusarium graminearum is considered as the primary producer of zearalanone. It is usually seen in moldy hay, high-moisture corn, corn infected before harvest etc.

Application

Zearalanone has been used:

• as mycotoxin to study its effects on the histology of ovaries in pre-pubertal bitches
• as a mycotoxin to investigate its influence on selected immunological, haematological and biochemical indexes in bitches
• as a standard to develop calibration curves in order to study its effects on progesterone and 17β-estradiol concentrations in peripheral blood and body weights of pre-pubertal female Beagle dogs
• as a standard to develop calibration curves to study its level of intoxication in women with neoplastic lesions in the reproductive tract

Actions biochimiques/physiologiques

Zearalanone is believed to cause vulvovaginitis and estrogenic responses in swine.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302 + H312 + H332,H315,H319,H335,H351
• Conseils de prudence: P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges