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W1520

Sigma-Aldrich

WAY-200070

≥98% (HPLC)

Synonyme(s) :

7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol, 7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol

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About This Item

Formule empirique (notation de Hill):
C13H8BrNO3
Numéro CAS:
440122-66-7
Poids moléculaire :
306.11
Numéro MDL:
MFCD16618385
Code UNSPSC :
51111800
ID de substance PubChem :
329830426
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

solid

Solubilité

DMSO: ≥20 mg/mL

Auteur

Wyeth

Température de stockage

2-8°C

Chaîne SMILES 

Oc1ccc(cc1)-c2nc3cc(O)cc(Br)c3o2

InChI

1S/C13H8BrNO3/c14-10-5-9(17)6-11-12(10)18-13(15-11)7-1-3-8(16)4-2-7/h1-6,16-17H

Clé InChI

BAAILVWEAXFTSF-UHFFFAOYSA-N

Description générale

WAY-200070 is a potent, selective estrogen receptor-beta (ER-β) agonist (IC50 2.3 nM vs. 155 nM for ER-α) with anxiolytic-like and antidepressant-like effects.

Application

WAY-200070, a selective estrogen receptor-beta (ER-β) agonist, may be used in estrogen receptor signaling research along with other ERβ agonists [diarylpropionitrile (DPN)] and antagonist to help identify and differentiate the functions of estrogen receptor-beta(s) (ER-β) involved in processes such as regulation of the physiology of the endocrine pancreas; modulation of visceral pain; and stress response. WAY-200070 may be used to help establish that an observed physiological or cell signaling response is ER-β-dependent, especially versus ERα.

Actions biochimiques/physiologiques

Potent, selective estrogen receptor-beta (ER-β) agonist (IC50 2.3 nM vs 155 nM for ER-α) with anxiolytic-like and antidepressant-like effects.

Caractéristiques et avantages

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301,H319

Classification des risques

Acute Tox. 3 Oral - Eye Irrit. 2

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Amy E Clipperton-Allen et al.
Psychoneuroendocrinology, 36(7), 981-995 (2011-01-21)
Gonadal hormones mediate both affiliative and agonistic social interactions. Research in estrogen receptor alpha (ERα) or beta (ERβ) knockout (KO) mice suggests that ERα increases and ERβ decreases male aggression, while the opposite is found for female ERαKO and ERβKO
Paloma Alonso-Magdalena et al.
Diabetes, 62(6), 2015-2025 (2013-01-26)
The estrogen receptor β (ERβ) is emerging as an important player in the physiology of the endocrine pancreas. We evaluated the role and antidiabetic actions of the ERβ selective agonist WAY200070 as an insulinotropic molecule. We demonstrate that WAY200070 enhances
Lidia I Serova et al.
The Journal of endocrinology, 205(3), 253-262 (2010-03-30)
Previously, pretreatment with estradiol benzoate (EB) was found to modulate the response of hypothalamic-pituitary-adrenal (HPA) axis and gene expression in several catecholaminergic neuronal locations in ovariectomized (OVX) rats exposed to single immobilization stress (IMO). Here, we investigated the role of
Claus Lattrich et al.
Archives of gynecology and obstetrics, 289(1), 163-171 (2013-08-03)
Coexpression of estrogen receptors (ER) α and β is present in about half of all breast cancer cases. Whereas ERα is a well-established target for endocrine therapy with the selective estrogen receptor modulator tamoxifen, the applicability of ERβ as target
Matthew D Hale et al.
Biology of reproduction, 100(1), 149-161 (2018-07-17)
Estrogens regulate key aspects of sexual determination and differentiation, and exposure to exogenous estrogens can alter ovarian development. Alligators inhabiting Lake Apopka, FL, are historically exposed to estrogenic endocrine disrupting contaminants and are characterized by a suite of reproductive abnormalities
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