U4010
Urokinase from human kidney cells
lyophilized powder
Synonyme(s) :
u-Plasminogen activator
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About This Item
Produits recommandés
Niveau de qualité
Forme
lyophilized powder
Poids mol.
heavy chain 30,400 Da
light chain 2000 Da
Température de stockage
2-8°C
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Application
Urokinase from human kidney cells has been used as a component of digestion mix for three-dimensional fibrin culture. It has also been used in plasminogen activation assay.
Actions biochimiques/physiologiques
Urokinase is a protease that cleaves plasminogen to form plasmin. It binds to cell surface receptors (uPAR) from which it regulates cell adhesion and migration during tissue remodeling and which also activate intracellular signaling pathways. Urokinase is composed of three domains: the amino terminal domain which is homologous to epidermal growth factor is attached through a central kringle domain to the protease domain in the carboxyl terminus.
Urokinase was shown to augment proliferation of renal tumor cells.
Propriétés physiques
Supplied as a lyophilized powder containing human albumin, mannitol and NaCl.
The principle active ingredient is the low molecular weight form of urokinase, and consists of an A chain of 2,000 daltons linked by a sulfhydyl bond to a B chain of 30,400 daltons.
Autres remarques
Note: Higher activities are obtained when human plasminogen is used as substrate.
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Resp. Sens. 1
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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