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T3126

Sigma-Aldrich

DL-α-Tocopherol succinate

semisynthetic, 1210 IU/g

Synonyme(s) :

Vitamin E succinate

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About This Item

Formule empirique (notation de Hill):
C33H54O5
Numéro CAS:
4345-03-3
Poids moléculaire :
530.78
Numéro Beilstein :
4038233
Numéro CE :
224-403-8
Numéro MDL:
MFCD00072055
Code UNSPSC :
12352205
eCl@ss :
34058016
ID de substance PubChem :
24900107
Nomenclature NACRES :
NA.28

Source biologique

semisynthetic

Forme

powder

Activité spécifique

1210 IU/g

Couleur

white to yellow

Température de stockage

room temp

Chaîne SMILES 

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(=O)CCC(O)=O)c(C)c(C)c2O1

InChI

1S/C33H54O5/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-20-33(8)21-19-28-27(7)31(25(5)26(6)32(28)38-33)37-30(36)18-17-29(34)35/h22-24H,9-21H2,1-8H3,(H,34,35)/t23-,24-,33-/m1/s1

Clé InChI

IELOKBJPULMYRW-NJQVLOCASA-N

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Description générale

α-Tocopherol succinate is a fat soluble vitamin. α-Tocopherol is a form of vitamin E, which can be obtained through dietary sources. RRR-α-tocopherol is a natural form of α-Tocopherol.

Application

D-α-Tocopherol succinate has been used:
  • to as a dietary supplement to study its immunomodulatory effects in chicks
  • as a dietary supplement in pregnant women to evaluate its effects on arsenic exposure
  • as an antioxidant to investigate concurrent pathways of cell death due to acute exercise

Actions biochimiques/physiologiques

α-Tocopherol is also called as a radical-chain breaker due to its anti-oxidant property.
Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. α-Tocopherol succinate is used along the α-Tocopherol acetate, α-Tocopherol nicotinate and other esterified forms as a vitamin E supplement with similar but differential activities.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Effects of immunomodulatory nutrients on growth performance and immune-related gene expression in layer chicks challenged with lipopolysaccharide
Wils-Plotz EL and Klasing KC
Poultry Science, 96(3), 548-555 (2017)
J S Drukteinis et al.
Placenta, 26 Suppl A, S87-S95 (2005-04-20)
Maternal cigarette smoking is known to disrupt placental growth and function. The polyaromatic hydrocarbon benzo[a]pyrene (BaP) is a major toxicant in cigarette smoke that has been shown to alter placental cell function. This study compared the effects of the benzo[a]pyrene
Vijay K Singh et al.
International immunopharmacology, 9(12), 1423-1430 (2009-09-09)
Vitamin E is composed of a family of eight isomers known as tocols; consisting of four tocopherols and four tocotrienols that exist in four isomeric forms: alpha (alpha), beta (beta), gamma (gamma), and delta (delta). Earlier we have demonstrated the
Myocardial apoptosis and mesenchymal stem cells with acute exercise
Arisi MF, et al.
Physiological Reports, 5(11), e13297-e13297 (2017)
Wenbin Zhu et al.
PloS one, 9(3), e92992-e92992 (2014-03-26)
Benzo[a]pyrene (BaP), a well-known environmental carcinogen, promotes oxidative stress and DNA damage. Curcumin and vitamin E (VE) have potent antioxidative activity that protects cells from oxidative stress and cellular damage. The objectives of the present study were to investigate the
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