T1450
Anti-γ-Tubulin (LL-17) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonyme(s) :
Anti-γ-Tubulin (LL-17)
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
antigen 48 kDa
Espèces réactives
Caenorhabditis elegans
Technique(s)
western blot: 0.75-1.5 μg/mL using whole extract of C. elegans.
Conditions d'expédition
dry ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
Caenorhabditis elegans ... Tbg-1(176361)
Catégories apparentées
Description générale
γ-Tubulin is a widely expressed and highly conserved protein within the microtubule organizing centers (MTOCs) or centrosome in eukaryotic cells. It is a member of the tubulin superfamily of proteins, which includes α and β tubulin and the newly discovered centrosomal-associated proteins, δ and ε tubulin. γ-Tubulin abundance is less than 1% of the level of either α or β tubulin.
Immunogène
synthetic peptide corresponding to the C-terminus of C. elegans γ-tubulin (amino acids 428-444) with N-terminal added cysteine, conjugated to KLH. This sequence is highly specific for C. elegans γ-tubulin, and not found in γ-tubulin sequences of other species or other members of the tubulin family such as α-, β-, δ-, and ε-tubulins.
Application
Anti-γ-Tubulin (LL-17) antibody produced in rabbit has been used in immunoblotting.
Actions biochimiques/physiologiques
γ-Tubulin has an essential role in microtubule nucleation by the centrosomes. γ-Tubulin does not polymerize with α-tubulin/β-tubulin, but instead it is localized to the centrosome and to the cytoplasm. γ-Tubulin is found as part of a large protein complex containing at least five other proteins and has a shape of a ring (γ-tubulin ring complex, γ-TuRC) that is roughly the same diameter as a microtubule. γ-Tubulin binds the microtubule minus ends and is responsible for mediating the link between microtubules and the centrosome.
Description de la cible
γTubulin (LL-17) is a widely expressed and highly conservedprotein within the microtubule organizing centers (MTOCs) or centrosome in eukaryotic cells.
Forme physique
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vous ne trouvez pas le bon produit ?
Essayez notre Outil de sélection de produits.
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
nwg
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Maria C Ow et al.
Genes & development, 22(18), 2520-2534 (2008-09-17)
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally via antisense base-pairing. Although miRNAs are involved in a variety of important biological functions, little is known about their transcriptional regulation. Using yeast one-hybrid assays, we identified transcription factors
An abundance of tubulins
Oakley BR
Trends in Cell Biology, 10(12), 537-542 (2000)
Heidi N Fridolfsson et al.
The Journal of cell biology, 191(1), 115-128 (2010-10-06)
Kinesin-1 and dynein are recruited to the nuclear envelope by the Caenorhabditis elegans klarsicht/ANC-1/Syne homology (KASH) protein UNC-83 to move nuclei. The mechanisms of how these motors are coordinated to mediate nuclear migration are unknown. Time-lapse differential interference contrast and
δ-tubulin and ?-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function
Chang P, et al.
Nature Cell Biology, 2(1), 30-30 (2000)
Nikhita Anand et al.
Neurobiology of disease, 139, 104786-104786 (2020-02-08)
Mutations in the human ATP13A2 gene are associated with an early-onset form of Parkinson's disease (PD) known as Kufor Rakeb Syndrome (KRS). Patients with KRS show increased iron deposition in the basal ganglia, suggesting iron toxicity-induced neurodegeneration as a potential
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique