SRP6158
EPO human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonyme(s) :
EP, EPO-alpha, Epoetin, Erythropoietin-alpha, MGC138142
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About This Item
Produits recommandés
Source biologique
human
Produit recombinant
expressed in HEK 293 cells
Pureté
≥95% (SDS-PAGE)
Forme
lyophilized
Poids mol.
36 kDa (monomer, glycosylated)
Conditionnement
pkg of 10 μg
Technique(s)
cell culture | mammalian: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−70°C
Informations sur le gène
human ... EPO(2056)
Description générale
The gene EPO (erythropoietin) is mapped to human chromosome 7q22. It is a glycoprotein hormone. EPO is generated in fetal liver and adult kidney. However, it can also be secreted by other organs, such as the heart, brain and lungs. EPO is a member of the EPO/TPO (thrombopoietin) family and is found in the plasma.
Application
- EPO (erythropoietin) has been used as a component of the culture medium for cardiac stem cells.
- In cultured cerebellar granule cells and hippocampal neurons, it has been used to study effect of EPO on glutamate release.
- It has also been used as a component of endothelial differentiation medium.
Actions biochimiques/physiologiques
EPO (erythropoietin) regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. It interacts with EPO receptor and is responsible for the cellular responses. EPO is expressed in many cancers, including breast cancer, renal cancer, gastric cancer, hepatocellular carcinoma and central nervous system tumors. In addition, it is a hypoxia responsive cytokine and a pro-angiogenic factor. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. It can protect from brain damages due to ischemia and enhances memory as well as cognitive ability in humans suffering from vascular dementia.
Forme physique
Lyophilized from a PBS solution.
Notes préparatoires
Centrifuge the vial prior to opening.
Reconstitution
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Les clients ont également consulté
Beth J Allison et al.
Journal of applied physiology (Bethesda, Md. : 1985), 126(1), 44-50 (2018-11-02)
Erythropoietin (EPO) is being trialled in preterm infants to reduce brain injury, but high doses increase lung injury in ventilated preterm lambs. We aimed to determine whether early administration of lower doses of EPO could reduce ventilation-induced lung injury and
Tessa Wilkin et al.
Drug testing and analysis, 9(9), 1456-1471 (2017-03-30)
A horse's success on the racetrack is determined by genetics, training and nutrition, and their translation into physical traits such as speed, endurance and muscle strength. Advances in genetic technologies are slowly explaining the roles of specific genes in equine
Identification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristics.
Fang B, et al.
Blood, 105, 2733-2740 (2005)
Zhihong Yang et al.
International journal of clinical and experimental pathology, 8(4), 4033-4043 (2015-06-23)
To evaluate erythropoietin (Epo) and erythropoietin receptor (EpoR) expression, its relationship with vasculogenic mimicry (VM) and its prognostic value in human hepatocellular carcinoma (HCC), we examined Epo/EpoR expression and VM formation using immunohistochemistry and CD31/PAS (periodic acid-Schiff) double staining on
Micro and nano-scale in vitro 3D culture system for cardiac stem cells.
Hosseinkhani H, et al.
Journal of Biomedical Materials Research Part A, 94, 1-8 (2010)
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