SRP6002
Chemerin human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonyme(s) :
HP10433, RARRES2, TIG2
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About This Item
Numéro CAS:
Code UNSPSC :
12352200
Produits recommandés
Source biologique
human
Produit recombinant
expressed in E. coli
Pureté
≥98% (HPLC)
≥98% (SDS-PAGE)
Forme
lyophilized
Poids mol.
16.0 kDa
Conditionnement
pkg of 25 μg
Impuretés
Endotoxin, tested
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Informations sur le gène
human ... RARRES2(5919)
Description générale
Chemerin, which is also known as retinoic acid receptor responder 2 (RARRES2), is a chemoattractant expressed in white adipose, liver and lung tissues. It is an immunomodulating factor. The protein is a ligand for the G-protein coupled receptor known as ChemR23 (or chemokine-like receptor-1), which is expressed mainly on dendritic cells, macrophages and some adipocytes. The gene encoding it is localized on human chromosome 7q36.1. Recombinant human Chemerin, produced in Escherichia.coli, is a non-glycosylated protein containing 138 amino acids and having a total molecular mass of 16kDa.
Actions biochimiques/physiologiques
Chemerin activates chemerin-like receptor 1 (CMKLR1) and stimulates chemotaxis in macrophages, natural killer cells and immature dendritic cells. It is also involved in the activation of extracellular signal-regulated kinases, stimulation of blood vessel formation, migration and invasion.
Forme physique
Lyophilized from 0.2% TFA.
Reconstitution
Centrifuge the vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile H?O to a concentration of 0.1mg/ml, which can be further diluted into other aqueous solutions.
Code de la classe de stockage
13 - Non Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Rui-Li Zhang et al.
Journal of cellular biochemistry, 120(12), 19621-19634 (2019-07-20)
Chemerin, a chemoattractant protein, is involved in endothelial dysfunction and vascular inflammation in pathological conditions. In a recent study, we observed the upregulation of chemerin in endothelial cells following in vitro treatment with Treponema pallidum. Here, we investigated the role
Jun-xian Zhou et al.
Acta pharmacologica Sinica, 35(5), 653-663 (2014-03-25)
The chemerin receptor CMKLR1 is one type of G protein-coupled receptors abundant in monocyte-derived dendritic cells and macrophages, which plays a key role in the entry of a subset of immunodeficiency viruses including HIV/SIV into lymphocytes and macrophages. The aim
Valérie Wittamer et al.
The Journal of experimental medicine, 198(7), 977-985 (2003-10-08)
Dendritic cells (DCs) and macrophages are professional antigen-presenting cells (APCs) that play key roles in both innate and adaptive immunity. ChemR23 is an orphan G protein-coupled receptor related to chemokine receptors, which is expressed specifically in these cell types. Here
Association of Polymorphisms in STRA6 and RARRES2 Genes with Type 2 Diabetes in Southern Han Chinese.
Huang HW
BioMed Research International, 2016, 6589793-6589793 (2016)
The commensal skin microbiota triggers type I IFN-dependent innate repair responses in injured skin.
Jeremy Di Domizio et al.
Nature immunology, 21(9), 1034-1045 (2020-07-15)
Skin wounds heal by coordinated induction of inflammation and tissue repair, but the initiating events are poorly defined. Here we uncover a fundamental role of commensal skin microbiota in this process and show that it is mediated by the recruitment
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