SRP2067

CAR, ligand binding domain (101-348) human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

• Synonyme(s) : CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.26

Propriétés

• Source biologique: human
• Produit recombinant: expressed in E. coli
• Pureté: ≥85% (SDS-PAGE)
• Forme: frozen liquid
• Poids mol.: ~30 kDa
• Conditionnement: pkg of 10 μg
• Conditions de stockage: avoid repeated freeze/thaw cycles
• Concentration: 500 μg/mL
• Couleur: clear; colorless
• Numéro d'accès NCBI: NM_005122
• Numéro d'accès UniProt: Q14994
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Informations sur le gène: human ... NR1I3(9970)

Description

Actions biochimiques/physiologiques

The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively active, it can be further activated by `phenobarbitol-like` compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, have been shown to place a role in bile acid clearance and cholestatic liver injury.

Forme physique

Clear and colorless frozen liquid solution

Notes préparatoires

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable