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Key Documents

SRP2050

RAR, β human

Name: RAR, β human
Brand: SIGMA

recombinant, expressed in E. coli, ≥75% (SDS-PAGE)

Synonyme(s) :

HAP, NR1B2, RRB2

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About This Item

Code UNSPSC :

12352202

Nomenclature NACRES :

NA.26

Source biologique

human

Produit recombinant

expressed in E. coli

Pureté

≥75% (SDS-PAGE)

Forme

frozen liquid

Poids mol.

~52.5 kDa

Conditionnement

pkg of 5 μg

Conditions de stockage

avoid repeated freeze/thaw cycles

Concentration

250 μg/mL

Couleur

clear colorless

Numéro d'accès NCBI

NM_000965

Numéro d'accès UniProt

P10826

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... RARB(5915)

Actions biochimiques/physiologiques

Retinoic acid receptors are important in the regulation of growth and differentiation of epithelial tissues, embryonic and central nervous system development and hematopoiesis. Retinoids mediate their effect by two classes of nuclear receptor proteins, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), that each consist of three isotypes ( α, β, and γ) encoded in separate genes. Upon dimerization with RXR, RARs can bind to specific enhancer sequences in the DNA, so-called retinoic acid response elements (RAREs), resulting in transcriptional activation of target genes in the presence of ligand. Retinoids, the natural and synthetic vitamin A derivatives, are known to inhibit the proliferation of lung cancer and breast cancer cells and the growth of carcinogen-induced bronchogenic squamous cell carcinoma and mammary tumors, and have been used as chemoprevention agents against both types of cancer. A growing body of evidence supports the hypotheses that the RAR beta gene is a tumor suppressor gene and the chemopreventive effects of retinoids are due to induction of RAR beta. RAR beta expression is reduced in many malignant tumors including breast carcinoma.

Forme physique

Clear and colorless frozen liquid solution

Notes préparatoires

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Retinoic acid receptors: transcription factors modulating gene regulation, development, and differentiation.

E Linney

Current topics in developmental biology, 27, 309-350 (1992-01-01)

Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?

P Kastner et al.

Cell, 83(6), 859-869 (1995-12-15)

Multiplicity generates diversity in the retinoic acid signalling pathways.

M Leid et al.

Trends in biochemical sciences, 17(10), 427-433 (1992-10-01)

Complexity in the retinoid signalling system arises from a combination of several forms of retinoic acid, multiple cytoplasmic binding proteins and nuclear receptors, and the existence of polymorphic retinoic acid response elements. Additional diversity appears to be generated by heterodimeric

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