SML3119

SHP1 Inhibitor, TPI-1

≥98% (HPLC)

• Synonyme(s) : 2-(2,5-Dichloro-phenyl)-[1,4]benzoquinone; 2-(2?,5?-Dichlorophenyl)-1,4-benzoquinone, 2-(2,5-Dichlorophenyl)-2,5-cyclohexadiene-1,4-dione, TPI 1, TPI-1, TPI1
• Formule empirique (notation de Hill): C₁₂H₆Cl₂O₂
• Numéro CAS: 79756-69-7
• Poids moléculaire : 253.08
• Numéro MDL: MFCD00448731
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 2 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C1C=CC(C(C2=C(C=CC(Cl)=C2)Cl)=C1)=O
• InChI: 1S/C12H6Cl2O2/c13-7-1-3-11(14)9(5-7)10-6-8(15)2-4-12(10)16/h1-6H
• Clé InChI: ZKHFYORNAYYOTM-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

TPI-1 is an orally bioavailable, noncytotoxic benzoquinone compound that acts as a potent irreversible inhibitor of SHP-1 (Src homology region 2 domain-containing phosphatase 1) catalytic domain (IC50 ~ 40 nM or 0.01 μg/ml) with selectivity over SHP-2 (IC50 ~ 0.1 μg/ml), MKP1 (IC50 > 1 μg/ml) and CD45. TPI-1 potently induces mouse and human primary IFN-g+ cells both in vitro and in vivo. Effectively inhibits B16 melanoma tumors in mice (1 or 3 mg/kg, s.c., daily) and prolong the survival. TPI-1 is shown to be 50-fold more effective than sodium stibogluconate in cell-based assays and may non-specifically react with cysteine residues.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable