SML2801

Isoforskolin

≥95% (HPLC)

• Synonyme(s) : 6-Acetyl-7-deacetylforskolin, (3R,6S,6aS)-6-(acetyloxy)-3-ethenyldodecahydro-5S,10S,10bS-trihydroxy-3,4aR,7,7,10aR-pentamethyl-1H-naphtho[2,1-b]pyran-1-one, Coleonol B, 6β-Acetoxy-1α,7β,9α-trihydroxy-8,13-epoxy-labd-14-en-11-one, Isoforskolin
• Formule empirique (notation de Hill): C₂₂H₃₄O₇
• Numéro CAS: 64657-21-2
• Poids moléculaire : 410.50
• Numéro MDL: MFCD00078929
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: powder
• Activité optique: [α]/D -8 to -5°, c = 0.5 in chloroform-d
• Couleur: white to beige
• Solubilité: DMF:H₂O (9:1): 2 mg/mL, clear
• Température de stockage: −20°C
• Chaîne SMILES: CC(=O)O[C@@H]1[C@H](O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)C13)C=C
• InChI: 1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16?,17-,19-,20-,21+,22-/m0/s1
• Clé InChI: CLOQVZCSBYBUPB-VDCUXWMXSA-N

Description

Actions biochimiques/physiologiques

Isoforskolin is a naturally occurring diterpene with anti-inflammatory activity. It has been shown to downregulate the expression of proinflammatory compounds. In an experimental mouse model of Lyme Disease induced arthritis isoforskolin downregulated the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA). In a rat asthmatic model isoforskolin down-regulated production of transforming growth factor β1 (TGF-β1) and interleukin-1β (IL-1β) which was accompanied by inhibition of inflammation and airway remodeling.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H312
• Conseils de prudence: P280 - P302 + P352 + P312 - P362 + P364 - P501
• Classification des risques: Acute Tox. 4 Dermal
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3