SML1689

Eupatilin

from (Isolated from Artemisia sp.), ≥98% (HPLC), powder, lipophilic flavonoid

• Synonyme(s) : 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one, 5,7-Dihydroxy-3′,4′,6-trimethoxyflavone, NSC 122413
• Formule empirique (notation de Hill): C₁₈H₁₆O₇
• Numéro CAS: 22368-21-4
• Poids moléculaire : 344.32
• Numéro MDL: MFCD13194819
• Code UNSPSC : 12352200
• ID de substance PubChem : 329826018
• Nomenclature NACRES : NA.77

Propriétés

• Nom du produit: Eupatilin, ≥98% (HPLC)
• Source biologique: (Isolated from Artemisia sp.)
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated; protect from light
• Couleur: white to beige
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: −20°C
• Chaîne SMILES: O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=CC(O)=C(OC)C(O)=C31
• InChI: 1S/C18H16O7/c1-22-12-5-4-9(6-14(12)23-2)13-7-10(19)16-15(25-13)8-11(20)18(24-3)17(16)21/h4-8,20-21H,1-3H3
• Clé InChI: DRRWBCNQOKKKOL-UHFFFAOYSA-N

Description

Application

Eupatilin has been used to investigate its inhibitory effects on intracranial hemorrhage (ICH)-induced inflammation and its anti-inflammatory mechanisms in mouse BV2 cells, in vitro. It has also been used as a standard for its quantitative estimation in Artemisia extracts by microcolumn high performance liquid chromatography with diode array (HPLC-DAD) assay.

Actions biochimiques/physiologiques

Eupatilin is a flavone with anti-oxidative, anti-inflammatory, and anti-cancer properties.

Eupatilin is an important constituent in the leaves of Artemisia argyi and also an active component of DA-9601. It exhibits anti-apoptotic effects. Eupatilin provides protection against tumor necrosis factor α (TNF-α)-mediated inflammation in human umbilical vein endothelial cells. It is used in the treatment of gastritis and peptic ulcers. Eupatilin safeguards gastric epithelial cells from oxidative damage and smooth muscle cells from indomethacin-induced cell damage. Eupatilin lowers bile acid-stimulated hepatocyte apoptosis.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable