SML1225

Indisulam

≥98% (HPLC)

• Synonyme(s) : N-(3-chloro-1H-indol-7-yl)-4-sulfamoylbenzenesulfonamide, N₁-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide
• Formule empirique (notation de Hill): C₁₄H₁₂ClN₃O₄S₂
• Numéro CAS: 165668-41-7
• Poids moléculaire : 385.85
• Numéro MDL: MFCD00945325
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825730
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to pink
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: −20°C
• Chaîne SMILES: ClC1=CNC2=C1C=CC=C2NS(C3=CC=C(S(=O)(N)=O)C=C3)(=O)=O
• InChI: 1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
• Clé InChI: SETFNECMODOHTO-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in the G1/S transition.

Indisulam is synthetic sulfonamide compound. In vitro and in vivo studies point out that indisulam prevents retinoblastoma protein phosphorylation. Also, it inhibits cyclins A and B1 activity. Indisulam is known to promote apoptosis. Indisulam is a potent inhibitor of cellular dehydrogenases and thus, is likely to interfere with metabolic pathways such as malate-aspartate shuttle, glycolysis and gluconeogenesis.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319
• Conseils de prudence: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable