SML1157

Eact

≥98% (HPLC)

• Synonyme(s) : 3,4,5-Trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)-benzamide
• Formule empirique (notation de Hill): C₂₂H₂₄N₂O₅S
• Numéro CAS: 461000-66-8
• Poids moléculaire : 428.50
• Numéro MDL: MFCD03115431
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825687
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C(C1=CC(OC)=C(OC)C(OC)=C1)N(CCOC)C2=NC(C3=CC=CC=C3)=CS2
• InChI: 1S/C22H24N2O5S/c1-26-11-10-24(22-23-17(14-30-22)15-8-6-5-7-9-15)21(25)16-12-18(27-2)20(29-4)19(13-16)28-3/h5-9,12-14H,10-11H2,1-4H3
• Clé InChI: ZUXNHFFVQWADJL-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

E_act activates the Calcium-activated Chloride channel (CaCC) TMEM16A CaCC. E_act stimulates CaCC conductance in salivary gland cells and submucosal airway epithelial cells. The compound E_act also stimulates submucosal gland secretion in human bronchial tissue and smooth muscle contraction in mouse intestine.

In rat arterial myocytes, Eact [3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)benzamide] helps to activate chloride current and prevents estradiol synthesis in cultured mouse granulosa cells. It is a small molecule activator of TMEM16A (transmembrane member 16A), that activates TRPV1 (transient receptor potential cation channel subfamily V member 1) and generates pain and itch related symptoms. Eact also initiates endogenous TRPV1 expressed by DRG (dorsal root ganglion) neurons.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable