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Merck
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Key Documents

Autres documents

SML0293

Sigma-Aldrich

Telbivudine

≥98% (HPLC)

Synonyme(s) :

β-L-Thymidine, 1-(2-Deoxy-β-L-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-Pyrimidinedione, 2′-Deoxy-L-thymidine, Epavudine, L-Thymidine, NV 02B, Sebivo

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About This Item

Formule empirique (notation de Hill):
C10H14N2O5
Numéro CAS:
3424-98-4
Poids moléculaire :
242.23
Numéro MDL:
MFCD02683612
Code UNSPSC :
12352200
ID de substance PubChem :
329825300
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Activité optique

[α]/D -15 to -22°, c = 1 in H2O

Couleur

white to beige

Solubilité

H2O: 10 mg/mL (clear solution)

Température de stockage

2-8°C

Chaîne SMILES 

CC1=CN([C@@H]2C[C@@H](O)[C@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m1/s1

Clé InChI

IQFYYKKMVGJFEH-CSMHCCOUSA-N

Application

Telbivudine has been used to explore the mechanisms of telbivudine (LdT) induced creatine kinase (CK) elevation.

Actions biochimiques/physiologiques

Telbivudine is a nucleoside analog that is widely used to treat hepatitis B virus (HBV) infection.
Telbivudine is a synthetic molecule containing β-L-configuration. Telbivudine improves the estimated glomerular filtration rate (eGFR) in response to chronic hepatitis B (CHB). It prevents perinatal transmission and enhances the hepatitis B e antigen (HBeAg) seroconversion. It is also known to cause side effects such as creatine kinase (CK) elevation and fatal rhabdomyolysis.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Timothy P Wakeman et al.
Oncotarget, 8(48), 83975-83985 (2017-11-16)
Hexavalent chromium (Cr[VI]) is associated with occupational lung cancer and poses a significant public health concern. When exposed to Cr[VI], cells rapidly internalize this compound and metabolize it to Cr[III]. Byproducts of Cr[VI] metabolism include unstable Cr[V] and Cr[IV] intermediates
Faezeh Koohestani et al.
PloS one, 8(9), e75844-e75844 (2013-09-17)
Uterine leiomyomas (ULs) are benign tumors occurring in the majority of reproductive aged women. Despite the high prevalence of these tumors, little is known about their etiology. A hallmark of ULs is the excessive deposition of extracellular matrix (ECM), primarily
Xingfei Pan et al.
Scientific reports, 10(1), 13631-13631 (2020-08-14)
Few studies were conducted to assess safety and efficacy of continuous antiviral therapy administrated from preconception. In the present study, 136 eligible women with chronic HBV infection were recruited, and assigned to active chronic hepatitis B (CHB) (Group A, B
Zhaoping Yan et al.
Medicine, 97(31), e11716-e11716 (2018-08-05)
The aim of this study was to evaluate clinical efficacy of telbivudine in treatment of hepatitis B virus-associated glomerulonephritis (HBV-GN).A total of 43 HBV-GN patients combined with chronic hepatitis B were treated with telbivudine for 104 weeks. Serum levels of
Gang Huang et al.
Annals of surgery, 268(6), 943-954 (2018-03-10)
Despite antiviral treatment has been shown to reduce hepatocellular carcinoma (HCC) recurrence after curative treatment for hepatitis B virus (HBV)-related HCC in patients with high preoperative HBV-DNA levels, it is still unclear whether antiviral therapy is useful in reducing recurrence
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