SML0178

ARL-17477 dihydrochloride hydrate

≥98% (HPLC)

• Synonyme(s) : N-[4-[2-[[(3-chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboximidamide dihydrochloride hydrate
• Formule empirique (notation de Hill): C₂₀H₂₀ClN₃S·2HCl · xH₂O
• Numéro CAS: 866914-87-6
• Poids moléculaire : 442.83 (anhydrous basis)
• Numéro MDL: MFCD21608518
• Code UNSPSC : 12352202
• ID de substance PubChem : 329825207
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: H₂O: ≥5 mg/mL
• Auteur: AstraZeneca
• Température de stockage: 2-8°C
• Chaîne SMILES: O.Cl.Cl.Clc1cccc(CNCCc2ccc(NC(=N)c3cccs3)cc2)c1
• InChI: 1S/C20H20ClN3S.2ClH.H2O/c21-17-4-1-3-16(13-17)14-23-11-10-15-6-8-18(9-7-15)24-20(22)19-5-2-12-25-19;;;/h1-9,12-13,23H,10-11,14H2,(H2,22,24);2*1H;1H2
• Clé InChI: QOPATWWWZNTSQF-UHFFFAOYSA-N

Description

Application

ARL-17477 dihydrochloride hydrate may be used in cell signaling studies.

Actions biochimiques/physiologiques

ARL-17477 is an nNOS specific inhibitor. The IC₅₀ against rat nNOS is 35 nM and it has 100-fold selectivity over endothelial and inducible isoforms. ARL-17477 penetrates the brain, and reduces infarct size and reduces cerebral blood flow in several different rodent models of ischemic brain injury.

Caractéristiques et avantages

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H319
• Conseils de prudence: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable