SCP0004
γ Secretase Inhibitor
≥95% (HPLC)
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About This Item
Formule empirique (notation de Hill):
C26H41N3O5
Poids moléculaire :
475.62
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32
Produits recommandés
Essai
≥95% (HPLC)
Forme
lyophilized
Composition
Peptide Content, ≥85%
Conditions de stockage
protect from light
Température de stockage
−20°C
Amino Acid Sequence
Z-Leu-Leu-Nle-al
Description générale
Gamma-secretase is a protein complex containing presenilin, nicastrin, APH-1, and PEN-2. The leupeptin analogue Z-Leu-Leu-Nle-al (N-benzyloxycarbonyl-Leu-Leu-norleucinal; Benzyloxicarbonyl-Leu-Leu-Nle-CHO (LLNle)) and closely related peptides are used as protease and a gamma secretase inhibitors.
Application
γ Secretase Inhibitor has been used to study the suppressive miR-129 functions through inhibition on estrogen receptor 1 (ESR1) and NOTCH signaling in breast cancer stem cells.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Les clients ont également consulté
MiR-129 blocks estrogen induction of NOTCH signaling activity in breast cancer stem-like cells.
Xiao G, et al.
Oncotarget, 8(61), 103261-103261 (2017)
Tao Na et al.
BMC cancer, 20(1), 1064-1064 (2020-11-06)
Immunomodulatory activities of human mesenchymal stromal /stem cells (hMSCs) has been widely recognized as the most critical function of hMSCs for exerting its therapeutic effects. However, the detailed mechanisms responsible for regulating the immunomodulation of hMSCs still remain largely unknown.
Asha Acharya et al.
PloS one, 6(11), e27743-e27743 (2011-11-24)
Aortic valve calcification is the most common form of valvular heart disease, but the mechanisms of calcific aortic valve disease (CAVD) are unknown. NOTCH1 mutations are associated with aortic valve malformations and adult-onset calcification in families with inherited disease. The
Guodong Xiao et al.
Oncotarget, 8(61), 103261-103273 (2017-12-22)
Stem-like cells in tumor group featured the major role in the chemotherapy resistance of breast cancer, and the reduction of stem-like cells helped to perish the tumor when receiving chemotherapy. Smaller stem cells number indicated better therapeutic effect in vitro
Paola Scaffidi et al.
Nature cell biology, 10(4), 452-459 (2008-03-04)
The premature-ageing disease Hutchinson-Gilford Progeria Syndrome (HGPS) is caused by constitutive production of progerin, a mutant form of the nuclear architectural protein lamin A. Progerin is also expressed sporadically in wild-type cells and has been linked to physiological ageing. Cells
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