SAB5500125

Anti-Keratin 17 antibody, Rabbit monoclonal

recombinant, expressed in proprietary host, clone SP95, affinity isolated antibody

• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Produit recombinant: expressed in proprietary host
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: SP95, monoclonal
• Espèces réactives: human (tested)
• Réactivité de l'espèce (prédite par homologie): mouse, bovine, dog, rat
• Technique(s): flow cytometry: 1:100; immunoblotting: 1:25; immunohistochemistry: 1:100
• Isotype: IgG
• Numéro d'accès UniProt: Q04695
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... KRT17(3872)

Description

Description générale

Keratin 17 plays a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. It may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells" and also act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. It is required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state and modulates the function of TNF-alpha in the specific context of hair cycling. It regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway and is involved in tissue repair. Keratin 17 is expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. It is also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).

Immunogène

Synthetic peptide corresponding to C-terminus of human keratin 17 protein.

Caractéristiques et avantages

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Forme physique

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable