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Key Documents

SAB5200077

Sigma-Aldrich

Monoclonal Anti-KCNB1 antibody produced in mouse

clone S89-34, 1 mg/mL, purified immunoglobulin

Synonyme(s) :

Anti-DRK1PC, Anti-Kcnb1, Anti-Kcr1-1, Anti-Kv2.1, Anti-Kv2.1, S89-34, Anti-Shab

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

S89-34, monoclonal

Forme

buffered aqueous glycerol solution

Poids mol.

antigen predicted mol wt 105-125 kDa

Espèces réactives

human, mouse, rat

Concentration

1 mg/mL

Technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotype

IgG1

Numéro d'accès NCBI

NP_037318

Numéro d'accès UniProt

Q14721

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

rat ... Kcnb1(25736)

Description générale

Potassium voltage-gated channel subfamily B member 1 (KCNB1) is widely distributed in the central nervous system. The gene ID for the protein is 25736.

Spécificité

Detects ~105-125 kDa (varies with cell background due to phosphorylation). No crossreactivity to rat Kv2.2.

Immunogène

Synthetic peptide amino acids 837-853 (cytoplamsic Cterminus) of rat KV2.1(HMLPGGGAHGSTRDQSI),Accession Number NP_037318.

Actions biochimiques/physiologiques

Potassium voltage-gated channel subfamily B member 1 (KCNB1) forms microdomains to aid in protein trafficking and has a role in smooth muscle contraction. KCNB1 also takes part in membrane fusion activities. Studies on Chinese hamster ovary (CHO) cells have shown that this protein has a role in apoptosis.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Anastasia Grizel et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 9(5), 727-739 (2014-09-27)
Voltage-gated potassium Kv2.1 channels are widely distributed in the central nervous system, specifically in neuroendocrine and endocrine cells. Their cytoplasmic C-termini are large and carry out many important functions. Here we provide the first direct structural evidence that each C-terminal
Emily Deutsch et al.
Molecular biology of the cell, 23(15), 2917-2929 (2012-06-01)
Voltage-gated K(+) (Kv) channels regulate membrane potential in many cell types. Although the channel surface density and location must be well controlled, little is known about Kv channel delivery and retrieval on the cell surface. The Kv2.1 channel localizes to
Yasushi Hosoi et al.
Frontiers in molecular neuroscience, 15, 806798-806798 (2022-12-06)
Fetal and infant brains are rich in maternally derived taurine. We previously demonstrated that taurine action regulates the cation-chloride cotransporter activity and the differentiation and radial migration of pyramidal neuron progenitors in the developing neocortex of rodent fetuses. Here we
Tekla Kirizs et al.
The European journal of neuroscience, 39(11), 1771-1783 (2014-03-13)
Potassium channels comprise the most diverse family of ion channels and play critical roles in a large variety of physiological and pathological processes. In addition to their molecular diversity, variations in their distributions and densities on the axo-somato-dendritic surface of

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