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Key Documents

SAB4500889

Sigma-Aldrich

Anti-FGFR2 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

BEK, BFR-1, ECT1, FGFR-2, Fibroblast growth factor receptor 2 precursor

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About This Item

Numéro MDL:
MFCD02096345
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 92 kDa

Espèces réactives

human, mouse

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

P21802

Numéro d'accès UniProt

P21802

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... FGFR2(2263)

Description générale

Anti-FGFR2 Antibody detects endogenous levels of total FGFR2 protein.

Fibroblast growth factor receptor 2 (FGFR2), a membrane-spanning tyrosine kinase belongs to the fibroblast growth factor (FGF) family. It is expressed in epithelium, developing central nervous system and in bone rudiments. It is located on human chromosome 10q26.

Immunogène

The antiserum was produced against synthesized peptide derived from human FGFR2.

Immunogen Range: 471-520

Actions biochimiques/physiologiques

Fibroblast growth factor receptor 2 (FGFR2) mutations show poor clinical diagnosis in endometrioid endometrial cancer. The FGFR2 gene participates in directional epithelial-mesenchymal signaling in the endometrium. It is essential for placentation and limb induction.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes
Pollock PM, et al.
Oncogene, 26, 7158-7162 (2007)
The imprinted gene and parent-of-origin effect database now includes parental origin of de novo mutations
Glaser RL, et al.
Nucleic Acids Research (2006)
FGFR2 mutations are associated with poor outcomes in endometrioid endometrial cancer: An NRG Oncology/Gynecologic Oncology Group study.
Jeske YW
Gynecologic Oncology, 145, 366-366 (2017)
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
Xu X, et al.
Development, 125, 753-765 (1998)
Masako Yokota et al.
PloS one, 9(7), e101693-e101693 (2014-07-09)
Apert syndrome is an autosomal dominantly inherited disorder caused by missense mutations in fibroblast growth factor receptor 2 (FGFR2). Surgical procedures are frequently required to reduce morphological and functional defects in patients with Apert syndrome; therefore, the development of noninvasive

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