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Key Documents

SAB4301041

Sigma-Aldrich

Anti-CD163 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

M130, MM130

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About This Item

Code UNSPSC :
12352203

Source biologique

rabbit

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human

Concentration

2.9 mg/mL

Technique(s)

immunohistochemistry: 1:25- 1:100

Isotype

IgG

Numéro d'accès

NP_004235.4

Numéro d'accès UniProt

Q86VB7

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CD163(9332)

Description générale

Cluster of differentiation 163 (CD163) is a hemoglobin scavenger receptor, encoded by a gene mapped to human chromosome 12p13.31. It is expressed on the surface of activated macrophages. The encoded protein is a member of scavenger receptor cysteine-rich family (SRCR) and is specifically expressed on cells of the monocyte/macrophage lineage.

Spécificité

The antibody detects endogenous levels of total CD163 protein.

Immunogène

Synthetic peptide corresponding to residues near the C terminal of human CD163 molecule

Actions biochimiques/physiologiques

Cluster of differentiation 163 (CD163) modulates anti-inflammatory functions and has a role in hemoglobin-haptoglobin clearance. Various cytokines influence the expression of CD163. It may be associated with hepatocellular carcinoma. Soluble CD163 level in serum acts as a potent indicator of the progression of cirrhosis and portal hypertension.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis.
Constantine C C, et al.
BMC Medical Genetics, 9(1), 18-18 (2008)
Role of Serum Soluble CD163 in the Diagnosis, Risk of Bleeding, and Prognosis of Gastro-Esophageal Varices in Cirrhotic Patients.
Fouad R, et al.
Journal of Interferon & Cytokine Research, 37(3), 112-118 (2017)
Macrophage activation marker soluble CD163 may predict disease progression in hepatocellular carcinoma.
Kazankov K, et al.
Scandinavian Journal of Clinical and Laboratory Investigation, 76(1), 64-73 (2016)
Clinical significance of soluble CD163 in polymyositis-related or dermatomyositis-related interstitial lung disease.
Enomoto Y, et al.
Arthritis Research & Therapy, 19(1), 9-9 (2017)
C Buechler et al.
Journal of leukocyte biology, 67(1), 97-103 (2000-01-27)
CD163, also referred to as M130, a member of the scavenger receptor cysteine-rich family (SRCR) is exclusively expressed on cells of the monocyte lineage. In freshly isolated monocytes the CD14bright CD16+ monocyte subset revealed the highest expression of CD163 among

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