SAB4301029
Anti-SLC34A2 antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
NAPI-3B, NAPI-IIb, NPTIIb
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Espèces réactives
human
Concentration
2.4 mg/mL
Technique(s)
immunohistochemistry: 1:100- 1:300
Isotype
IgG
Numéro d'accès
NP_001171469.1
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... SLC34A2(10568)
Description générale
Solute carrier family 34 member 2 (SLC34A2) is a transmembrane protein, which belongs to SLC34 family. The protein encoded by SLC34A2 is a sodium-dependent phosphate transporter type IIb (NaPi-IIb). It is a pH-sensitive transporter, expressed in small intestine, liver and lung. NaPi-IIb expression is also observed in female genital tract, endometrium, cervix, fallopian tube and not in ovary. In human chromosome, the gene SLC34A2 is localized on 4p15.2.
Spécificité
The antibody detects endogenous levels of total SLC34A2 protein.
Immunogène
Synthetic peptide corresponding to residues near the C terminal of human Solute carrier family 34 (sodium phosphate), member 2
Actions biochimiques/physiologiques
Solute carrier family 34 member 2 (SLC34A2) cotransports inorganic phosphate ion and sodium ion into epithelial cells. SLC34A2 is associated with various malignancies like papillary thyroid and breast carcinoma and lung adenocarcinoma. Knockdown of SLC34A2 downregulates phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signalling pathway, in turn inhibiting tumour cell proliferation and metastasis of hepatocellular carcinoma. SLC34A2 promotes tumour proliferation of bladder cancer, through upregulation of proto-oncogene c-Myc. Fetal and early embryonic development of lung requires high expression of SLC33A2 and is downregulated in NSCLC (non-small cell lung carcinoma). High expression of NaPi-IIb is observed in epithelial ovarian cancer. Overexpression of SLC34A2 promotes colorectal cancer progression. Mutations in SLC34A2 is related to pulmonary alveolar microlithiasis.
Caractéristiques et avantages
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Forme physique
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Overexpression of SLC34A2 is an independent prognostic indicator in bladder cancer and its depletion suppresses tumor growth via decreasing c-Myc expression and transcriptional activity
Ye W, et al.
Cell Death & Disease, 8(2), e2581-e2581 (2017)
Knockdown of SLC34A2 inhibits hepatocellular carcinoma cell proliferation and invasion
Li Y, et al.
Oncology Research, 24(6), 511-519 (2016)
A novel SLC34A2 mutation in a patient with pulmonary alveolar microlithiasis
Izumi H, et al.
Human Genome Variation, 4, 16047-16047 (2017)
Immunohistochemical evaluation of epithelial ovarian carcinomas identifies three different expression patterns of the MX35 antigen, NaPi2b
Levan K, et al.
BMC Cancer, 17(1), 303-303 (2017)
Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas
Yin BWT, et al.
Cancer immunology research, 8(1), 3-3 (2008)
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