SAB4300701
Anti-Id2 antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
Anti-GIG8, Anti-ID2A, Anti-ID2H
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About This Item
Code UNSPSC :
12352203
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
~15 kDa
Espèces réactives
rat, mouse, human
Concentration
1 mg/mL
Technique(s)
western blot: 1:500-1:1000
Isotype
IgG
Séquence immunogène
(S-P-V-R-S)
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... Id2(3398)
Description générale
Id2 (inhibitor of DNA binding 2) belongs to the HLH (helix–loop–helix) family. It is located on human chromosome 2p25.
The antibody detects endogenous level of total Id2 protein.
Immunogène
Peptide sequence around aa. 5-9 (S-P-V-R-S), according to the protein NP_002157.2
Actions biochimiques/physiologiques
Id2 (inhibitor of DNA binding 2) knockdown decreases the upregulation of N-cadherin, vimentin and Snail and promotes the expression of E-cadherin. It has the ability to interact with Rb protein and block its antiproliferative activity. It can prevent the separation of cells, stimulate multiplication of cell and help in reprogramming of Hodgkin lymphoma cells, the oncogenic AP-1 transcription factor FRA2 (fos-related antigen 2) and the oncogenic tyrosine kinase CSF-1 receptor.
Caractéristiques et avantages
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Description de la cible
ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression.
Forme physique
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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The Role of Id2 Protein in Neuroblatoma in Children
Wieczorek A and Balwierz W
Pathology Oncology Research, 21(4), 999-1004 (2015)
Targeting ID2 expression triggers a more differentiated phenotype and reduces aggressiveness in human salivary gland cancer cells
Sumida T, et al.
Genes Cells, 21(8), 915-920 (2016)
Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma
Mathas S, et al.
Proceedings of the National Academy of Sciences of the USA, 106(14), 5831-5836 (2009)
Ivan Ferrer-Vicens et al.
Cellular and molecular life sciences : CMLS, 71(18), 3583-3597 (2014-02-28)
The inhibitor of differentiation Id2, a protein lacking the basic DNA-binding domain, is involved in the modulation of a number of biological processes. The molecular mechanisms explaining Id2 pleiotropic functions are poorly understood. Id2 and E2F4 are known to bind
Sameer S Bajikar et al.
Developmental cell, 43(4), 418-435 (2017-11-22)
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous carcinoma in which various tumor-suppressor genes are lost by mutation, deletion, or silencing. Here we report a tumor-suppressive mode of action for growth-differentiation factor 11 (GDF11) and an unusual mechanism of
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