SAB4300644

Anti-TAZ antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : Anti-WWTR1
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: ~49 kDa
• Espèces réactives: rat, human, mouse
• Concentration: 1 mg/mL
• Technique(s): western blot: 1:500-1:1000
• Isotype: IgG
• Séquence immunogène: (V-E-S-A-L)
• Numéro d'accès NCBI: NM_001168278.1
• Numéro d'accès UniProt: Q16635
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... TAZ(25937)

Description

Description générale

The antibody detects endogenous level of total TAZ protein.

Immunogène

Peptide sequence around aa. 386-390 (V-E-S-A-L), according to the protein NP_001161750.1

Caractéristiques et avantages

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Description de la cible

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable