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Key Documents

SAB4300613

Sigma-Aldrich

Anti-Cry1 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-AU020726 antibody produced in rabbit, Anti-AU021000 antibody produced in rabbit, Anti-Phll1 antibody produced in rabbit, Anti-cryptochrome 1 (photolyase-like) antibody produced in rabbit

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

~60 kDa

Espèces réactives

mouse

Concentration

1 mg/mL

Technique(s)

western blot: 1:500-1:1000

Isotype

IgG

Séquence immunogène

(S-Q-G-S-G)

Numéro d'accès NCBI

NP_031797.1

Numéro d'accès UniProt

P97784

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Cry1(12952)

Description générale

Cry1 (cryptochrome circadian regulator 1) belongs to the cryptochrome family. It is located on human chromosome 12q23.

Immunogène

Peptide sequence around aa. 551-555 (S-Q-G-S-G), according to the protein Cry1.

Actions biochimiques/physiologiques

Cry1 (cryptochrome circadian regulator 1) controls gluconeogenesis. It induces tumor development and multiplication. Overexpression of Cry1 results in tumor progression and poor clinical indications in individuals with colorectal Cancer.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Description de la cible

Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Cryptochrome 1 overexpression correlates with tumor progression and poor prognosis in patients with colorectal cancer
Yu H, et al.
PLoS ONE (2013)
CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American
Dashti HS, et al.
Chronobiology International, 31(5), 660-667 (2014)
Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder
Soria V, et al.
Neuropsychopharmacology, 35(6), 1279-1289 (2010)

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