SAB4200773
Anti-Pentraxin 3 antibody, Mouse monoclonal
clone PTX3-5, purified from hybridoma cell culture
Synonyme(s) :
Pentaxin-related protein PTX3, TNF alpha-induced protein 5, TSG-14, Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Niveau de qualité
Forme d'anticorps
purified from hybridoma cell culture
Type de produit anticorps
primary antibodies
Clone
PTX3-5, monoclonal
Forme
buffered aqueous solution
Poids mol.
~47 kDa
Espèces réactives
human
Concentration
~1 mg/mL
Technique(s)
immunoblotting: 0.5-1 μg/mL using purified recombinant human Pentraxin 3 protein
immunoprecipitation (IP): 1-2 μg/test using lysate of HEK-293T cells over-expressing human Pentraxin 3
Isotype
IgG1
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... PTX3(5806)
Description générale
Anti-Pentraxin 3 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the PTX3-5 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mouse immunized with recombinant human pentraxin 3 protein expressed in HEK-293 cells. Pentraxin 3 (PTX3), also called tumor necrosis factor inducible gene 14 protein (TSG-14), is a highly glycosylated secreted protein usually found as covalently-bound homooctamers. PTX3 belongs to the pentraxin subfamily, sharing the C-terminal domain with short pentraxins and contains a unique N-terminal domain. PTX3 is majorly present in monocytes, macrophages, fibroblasts, endothelial cells and adipocytes. It is an acute-phase protein mapped to human chromosome 3q25.32.
Spécificité
Anti-Pentraxin 3 antibody, Mouse monoclonal recognizes both glycosylated and non-glycosylated human PTX3.
Immunogène
recombinant human Pentraxin 3 protein expressed in HEK-293 cells
Application
Anti-Pentraxin 3 antibody, Mouse monoclonal may be used in immunoblotting and immunoprecipitation.
Actions biochimiques/physiologiques
Pentraxin 3 (PTX3) is released in response to primary inflammatory signals, such as toll-like receptor engagement, tumor necrosis factor α (TNFα) and interleukin 1β (IL-1β). It regulates innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. PTX3 acts as a soluble pathogen recognition receptor and aids resistance against pathogens. It participates in the removal of apoptotic cells during an immune response. PTX3 associates with complement factor H and associates with synovial fluid in rheumatoid arthritis and also in conditions of sepsis. PTX3 is suppressed by pitavastatin, making it a biomarker for inflammatory cardiovascular disease.
Forme physique
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Stockage et stabilité
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Clause de non-responsabilité
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Pentraxin 3: a novel biomarker for inflammatory cardiovascular disease
Inoue K, et al.
International Journal of Vascular Medicine, 2012 (2012)
Narae Hwang et al.
Korean journal of ophthalmology : KJO, 30(6), 468-478 (2016-12-17)
To investigate the production of long pentraxin 3 (PTX3) in response to tunicamycin-induced endoplasmic reticulum (ER) stress and its role in ER stress-associated cell death, PTX3 expression was evaluated in the human retinal pigment epithelial cell line, ARPE-19. PTX3 production
F Fazzini et al.
Arthritis and rheumatism, 44(12), 2841-2850 (2002-01-05)
To verify whether the prototypical long pentraxin PTX3 represents an indicator of the activity of small-vessel vasculitis. Concentrations of PTX3, a pentraxin induced in endothelium by cytokines, were measured by enzyme-linked immunosorbent assay in the sera of 43 patients with
B Muller et al.
Critical care medicine, 29(7), 1404-1407 (2001-07-11)
To evaluate the recently discovered long pentraxin PTX3 in plasma of critically ill patients and to compare it with the classic short pentraxin C-reactive protein and with other indicators of inflammation. A cohort study on plasma samples. Medical intensive care
Kenji Inoue et al.
International journal of vascular medicine, 2012, 657025-657025 (2012-02-22)
Numerous studies have recently examined the role of pentraxin 3 (PTX3) in clinical situations. The pentraxin family includes C-reactive protein (CRP); however, unlike CRP, PTX3 is expressed predominantly in atherosclerotic lesions that involve macrophages, neutrophils, dendritic cells, or smooth muscle
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