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SAB4200684

Sigma-Aldrich

Monoclonal Anti-Uvomorulin/E-Cadherin antibody produced in rat

clone DECMA-1, purified from hybridoma cell culture

Synonyme(s) :

Arc-1, CD324, CDHE, E-cadherin (epithelial), ECAD, LCAM, UVO, cadherin 1, type 1

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About This Item

Code UNSPSC :
12352209
Nomenclature NACRES :
NA.41

Source biologique

rat

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

DECMA-1, monoclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~120 kDa

Espèces réactives

dog, mouse

Concentration

~1 mg/mL

Description générale

Monoclonal Anti-Uvomorulin/E-Cadherin (rat IgG1 isotype) is derived from the DECMA-1 hybridoma produced by the fusion of rat myeloma cells and splenocytes from an immunized Lou rat. Uvomorulin/E-Cadherin (Epithelial cadherin), also known as CDH1, CAM 120/80, L-CAM (Cell-Adhesion Molecule) or CD324, is a member of the cadherin transmembrane glycoproteins superfamily. It is characterized with a highly conserved cytoplasmic tail.

Immunogène

Mouse embryonal carcinoma cell line PCC4 Aza RI

Application

Monoclonal Anti-Uvomorulin/E-Cadherin antibody produced in rat has been used in various immunochemical techniques including immunoblotting, immunoprecipitation, immunohistochemical staining and immunofluorescent staining.

Actions biochimiques/physiologiques

Cadherins contribute to epithelial cell behavior and tissue morphogenesis/remodeling by facilitating cell-cell adhesion. Monoclonal Anti-Uvomorulin/E-Cadherin can be used for studies of embryonal development, cell-cell interaction of cells grown in culture, and localization of E-Cadherin. In addition, it is commonly used as an E-cadherin inhibitor/blocking antibody in a study of embryonic stem cells (EMS).
E-cadherin is a calcium-dependent glycoprotein. It is responsible for the homogeneous attachment between cells. It suppresses malignant transformation of tumors. Additionally, it also regulates cellular invasion and metastasis.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
116M4883V
026M4851V

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Consulter la Bibliothèque de documents

Yan Zhang et al.
Molecular medicine reports, 12(3), 3393-3399 (2015-05-16)
The aim of the present study was to investigate the expression and clinical significance of hypoxia-inducible factor 1α (HIF-1α), Snail and E-cadherin in ovarian cancer. The expression levels were assessed in a number of ovarian cancer cell lines and ovarian
Adherens and tight junctions: structure, function and connections to the actin cytoskeleton
Hartsock A and Nelson WJ
Biochimica et Biophysica Acta - Biomembranes, 1778(3), 660-669 (2008)
Repetto O., et al.,
BioMed Research International, 2014, 408047-408047 (2014)
Cadherin-mediated cell-cell interactions in normal and cancer cells
Gloushankova NA, et al.
Tissue barriers, 5(3), e1356900-e1356900 (2017)
Eun Ju Lee et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 20(7), 1424-1433 (2012-03-29)
The beneficial effects of stem cells in clinical applications to date have been modest, and studies have reported that poor engraftment might be an important reason. As a strategy to overcome such a hurdle, we developed the spheroid three dimensional
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