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SAB4200575

Sigma-Aldrich

Anti-SLC40A1 antibody produced in rabbit

IgG fraction of antiserum

Synonyme(s) :

Ferroportin-1(FPN1), HFE4, IREG1, MST079, MSTP079, MTP1, SLC11A3, solute carrier family 40 (iron-regulated transporter) member 1,

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Forme

buffered aqueous solution

Poids mol.

~60 kDa

Espèces réactives

rat, human

Technique(s)

immunoblotting: 1:1,000-1:2,000 using rat kidney extracts (S1 fraction)
immunohistochemistry: 1:50-1:100 using formalin-fixed paraffin-embedded human duodenum

Numéro d'accès UniProt

Q9NP59

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SLC40A1(30061)
rat ... Slc40a1(170840)

Description générale

SLC40A1 (also known as ferroportin, FPN1), also called iron-regulated transporter 1 (IREG1), is an iron transporter expressed in liver, duodenum and kidney. SLC40A1 is also expressed in the brain, duodenal mucosa, in neuronal cells and endothelial cells of the blood-brain barrier.

Immunogène

synthetic peptide corresponding to an internal sequence of human SLC40A1, conjugated to KLH.

Application

Anti-SLC40A1 antibody produced in rabbit has been used in western blotting and immunohistochemistry.

Actions biochimiques/physiologiques

Ferroportin 1(FPN1) plays a central role in systemic iron homeostasis and is critical for normal intestinal iron absorption. SLC40A1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure. Hepcidin binds to and inhibits solute carrier family FPN1, thus preventing enterocytes of the intestines from secreting iron into the hepatic portal system, thereby functionally reducing iron absorption. Ferroportin in neuronal cells is required for cellular Fe2+ export, a process critical for normal neuronal function. It has been shown to interact with amyloid precursor protein (APP), to facilitate the iron export process from neuronal cells. Mutations in the FPN1 gene have been linked to hereditary hemochromatosis, a common disorder characterized by iron overload and multi-organ damage.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Differential regulation of estrogen in iron metabolism in astrocytes and neurons
Xu M, et al.
Journal of Cellular Physiology, 234(4), 4232-4242 (2019)
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
Donovan A, et al.
Cell Metabolism, 1(3), 191-200 (2005)
Jinzhe Mao et al.
Development (Cambridge, England), 137(18), 3079-3088 (2010-08-13)
Neural tube defects (NTDs) are some of the most common birth defects observed in humans. The incidence of NTDs can be reduced by peri-conceptional folic acid supplementation alone and reduced even further by supplementation with folic acid plus a multivitamin.
A T McKie et al.
Molecular cell, 5(2), 299-309 (2000-07-06)
Iron absorption by the duodenal mucosa is initiated by uptake of ferrous Fe(II) iron across the brush border membrane and culminates in transfer of the metal across the basolateral membrane to the portal vein circulation by an unknown mechanism. We
Natascha A Wolff et al.
Journal of cellular and molecular medicine, 15(2), 209-219 (2009-12-18)
Ferroportin 1 (FPN1) is an iron export protein expressed in liver and duodenum, as well as in reticuloendothelial macrophages. Previously, we have shown that divalent metal transporter 1 (DMT1) is expressed in late endosomes and lysosomes of the kidney proximal
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